TWO-STEP MOLECULAR SURFACE IMPRINTING METHOD FOR MAKING A SENSOR
First Claim
1. A method for fabricating a surface-molecularly imprinted sensor, the method comprising:
- forming a molecule templatable film onto a support surface;
subsequently inserting template molecules onto the support surface and within the film; and
removing the template molecules from the film to create a plurality of cavities.
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Abstract
A method is provided for detecting target molecules (60) using a surface-molecularly imprinted sensor (52) and more particularly for detecting hydroxyl containing molecules, heavy metal ions, or thiol- or dialkylamine containing molecules by integrating molecular recognition and sensor transduction. The method includes soaking a support surface (14) in a solution containing a ligand molecule with headgroups that could adsorb on the surface of a substrate, or monomer to create a monolayer, a monolayer of polymerized organosiloxane groups (16), or a conducting film on the support surface (14). Template molecules (18) are then added to the imprinting solution so as to be positioned within the sparsely formed film, wherein the template molecules (18) comprise hydroxyl containing molecules, heavy metal ions, or thiol and dialkylamine containing molecules which prevents the interaction between monomer/ligand molecules and template molecules (18). In this case, there is a competitive reaction between the hydroxyl group on the surface of substrate and hydroxyl in ethanol molecule with monomer, e.g. OTS. The template molecules (18) are removed to define cavities in the imprinted film (16).
10 Citations
17 Claims
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1. A method for fabricating a surface-molecularly imprinted sensor, the method comprising:
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forming a molecule templatable film onto a support surface; subsequently inserting template molecules onto the support surface and within the film; and removing the template molecules from the film to create a plurality of cavities. - View Dependent Claims (3, 4, 5)
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2. The method of claim 2 wherein the molecule templatable film comprises one of self-assembling molecules or conducting polymers.
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6. A method for fabricating a surface-molecularly imprinted sensor, the method comprising:
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adsorbing ligand molecules with headgroups onto a support surface to form a self-assembled monolayer; subsequently adsorbing template molecules onto the support surface and within the self-assembled monolayer; and removing the template molecules from the self-assembled monolayer to create a plurality of cavities. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13)
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14. A method for making a surface-molecularly imprinted sensor, the method comprising:
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immerse an electrode in a solution containing a plurality of monomers to electropolymerize and create a film of a plurality of conducting polymers on a surface of the electrode; subsequently adding a plurality of template molecules to the solution to position the template molecules within the film; and removing the template molecules to create a plurality of cavities in the film. - View Dependent Claims (15, 16, 17)
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Specification