Gated Voltammetry
First Claim
1. A voltammetric method for determining the concentration of an analyte in a sample, comprising:
- applying a pulse sequence to the sample, the pulse sequence comprising at least two duty cycles;
measuring resulting currents; and
determining the concentration of the analyte in the sample.
2 Assignments
0 Petitions
Accused Products
Abstract
A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip.
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Citations
48 Claims
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1. A voltammetric method for determining the concentration of an analyte in a sample, comprising:
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applying a pulse sequence to the sample, the pulse sequence comprising at least two duty cycles; measuring resulting currents; and determining the concentration of the analyte in the sample. - View Dependent Claims (2, 3, 5, 8, 28, 29, 30, 31, 32)
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4. (canceled)
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6-7. -7. (canceled)
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9-26. -26. (canceled)
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33. A handheld analyte measuring device, for determining the concentration of an analyte in a sample, comprising a gated oltammetric measuring device adapted to receive a sensor strip, where
the gated oltammetric measuring device comprises at least two device contacts in electrical communication with a display through electrical circuitry, and the sensor strip comprises at least first and second sensor strip contacts, the first sensor strip contact in electrical communication with a working electrode and the second sensor strip contact in electrical communication with a counter electrode through conductors, where a first reagent layer is on at least one of the electrodes, the first reagent layer comprises an oxidoreductase and at least one species of a redox pair.
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34-35. -35. (canceled)
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36. A handheld measuring device, for determining the concentration of an analyte in a sample, where
the device is adapted to receive a sensor strip and the device comprises: -
at least two contacts; at least one display; and electrical circuitry establishing electrical communication between the at least two contacts and the at least one display, where the electrical circuitry includes a processor in electrical communication with an electric charger and a computer readable storage medium, where the processor is operable to implement a pulse sequence from the electric charger to the at least two contacts, where the pulse sequence comprises at least two duty cycles, where the processor is operable to measure at least one current profile at the at least two contacts, and where the processor is operable to determine the analyte in the sample in response to the at least one current profile. - View Dependent Claims (38)
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37. (canceled)
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39. A method of reducing the bias attributable to mediator background in a determined concentration of an analyte in a sample comprising:
applying a gated voltammetric pulse sequence to the sample, the pulse sequence comprising at least two duty cycles.
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40. A method of determining the duration of a pulse sequence including at least two duty cycles, for determining the concentration of an analyte in a sample comprising:
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determining a plurality of calibration sets determined from currents recorded during the at least two duty cycles; and determining the duration of the pulse sequence in response to the determined concentration of the analyte in the sample.
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41. (canceled)
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42. A method of signaling a user to add additional sample to a sensor strip, comprising:
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determining if the sensor strip is under-filled by comparing at least one current value recorded from a pulse sequence including at least two duty cycles to a pre-selected value; and signaling the user to add additional sample to the sensor strip if the strip is under-filled.
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43-45. -45. (canceled)
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46. A voltammetric method for determining the concentration of an analyte in a sample, comprising:
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applying a pulse sequence to the sample, the pulse sequence comprising at least two duty cycles having excitation/relaxation time ratios from 0.3 to 0.2; measuring resulting currents; and determining the concentration of the analyte in the sample. - View Dependent Claims (47)
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48. In an electrochemical method for determining the concentration of an analyte in a sample, the improvement comprising applying a gated voltammetric pulse sequence to the sample comprising at least two duty cycles.
Specification