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METHOD FOR DETERMINING OPTIMUM INTRAOCULAR LOCATIONS FOR DRUG DELIVERY IMPLANT

  • US 20080181929A1
  • Filed: 11/30/2007
  • Published: 07/31/2008
  • Est. Priority Date: 12/01/2006
  • Status: Active Grant
First Claim
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1. A method for determining an optimum intravitreal location for a drug delivery system for treating an ocular condition, wherein the ocular condition affects a retinal tissue, and wherein the drug delivery system comprises a therapeutic agent and a biodegradable polymer associated with the therapeutic agent, the method comprising the step of determining the value of x in Formula (I):


  • C=Coerfc[x/(2

    {square root over (Dt)}
    )] 



    (I)wherein, Co is the concentration of the therapeutic agent in retinal tissue adjacent to the implant, D is the coefficient for solution diffusion through the vitreous of the eye, t is time, erfc is the complementary error function, C is the desired concentration of the therapeutic agent in the retinal tissue, and x is the distance between the drug delivery system and the target retinal tissue, thereby determining the optimum intravitreal location for a drug delivery system for treating an ocular condition.

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