METHOD FOR PREDICTING A DRUG TRANSPORT CAPABILITY BY ABCG2 POLYMORPHISMS
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Abstract
The present invention provides polymorphisms of ABCG2 polypeptide and polynucleotide coding therefor, which is related to the intracellular accumulation of indolocarbazole compounds, as well as methods for detecting the polymorphisms, comprising collecting a sample from mammals, and determining a polymorphism of the nucleotide sequence of ABCG2 gene or a polymorphism of the amino acid sequence of ABCG2 polypeptide. In a preferred embodiment of the present invention, the polymorphism of the nucleotide sequence is one or more of single nucleotide polymorphisms at positions selected from the group consisting of 34, 376 and 421 of SEQ ID NO:1, and the polymorphism of the amino acid sequence is one or more of amino acid polymorphisms at positions consisting of 12, 126, and 141 of SEQ ID NO:2.
3 Citations
32 Claims
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1-18. -18. (canceled)
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19. A method for determining whether a cell carries a gene encoding an ABCG2 transporter protein with a decreased capacity to excrete compound B comprising:
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performing an assay on a biological sample from a human cell and determining the nucleotide present at position 34 of SEQ ID NO;
1, wherein the presence of the nucleotide A at position 34 indicates that the cell carries a gene encoding an ABCG2 transporter protein having a decreased capacity to excrete compound B compared to a gene having the nucleotide G at position 34 of SEQ ID NO;
1;wherein compound B is a compound of formula (I); - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification