Processes for preparing sertraline

• US 20080183015A1
• Filed: 01/09/2008
• Published: 07/31/2008
• Est. Priority Date: 02/23/2005
• Status: Active Grant

• Current Assignee: Teva Pharmaceutical Industries Limited, Teva Pharmaceuticals USA, Inc. (Teva Pharmaceutical Industries Limited)
• Original Assignee: Teva Pharmaceutical Industries Limited, Teva Pharmaceuticals USA, Inc. (Teva Pharmaceutical Industries Limited)
• Inventors: Kansal, Vinod Kumar, Ranjan, Harish, Singh, Pankaj, Nayal, Sanjay, Mendelovici, Marioara
• Granted Patent: US 7,518,018 B2
• Time in Patent Office: Days
• US Class Current: 564/308
• CPC Class Codes: C07C 209/52 by reduction of imines or imino-ethers C07C209/24 takes precedence
• CPC Class Codes: C07C 211/42 with six-membered aromatic rings being part of the condensed ring systems
• CPC Class Codes: C07C 2602/10 the other ring being six-membered, e.g. tetraline

Abstract

Provided are processes for the preparation of sertraline and sertraline hydrochloride.

Claims

1. A process for sertraline HCl comprising the steps of:

a) reducing sertraline-1-imine in a mixture with toluene and 1,2-dichlorobenzene with Raney Nickel under a hydrogen atmosphere to obtain a racemic mixture;

b) combining toluene and D(−

) mandeleic acid with the mixture to precipitate crude sertraline mandelate;

c) recrystallizing the crude mandelate from ethanol to obtain a purified mandelate salt;

d) converting the mandelate salt to the hydrochloride salt.