MEDICAL DEVICES WITH BROAD SPECTRUM ANTIMICROBIAL ACTIVITY
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Abstract
The present invention provides novel broad spectrum antiseptic compounds that further have properties that allow them to be coated/impregnated into polymer surfaces. Methods for coating these antiseptic compounds onto medical devices especially indwelling medical devices to prevent the growth of pathogens in such devices and hence, to prevent infection to patients via such devices are provided. The invention also provides antiseptics that are useful as general surface disinfectants and sterilizers, fluid disinfectants and biocide preservatives.
95 Citations
93 Claims
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1-54. -54. (canceled)
- 55. A medical device coated with a composition comprising a basic reagent and a dye, wherein the device is selected from the group consisting of an endotracheal tube, a vascular catheter, a nephrostomy tube, a stent, an orthopedic device, a prosthetic valve, a urinary catheter, a peritoneal catheter, an eptidural catheters a central nervous system catheter, a blood exchanging device, a vascular access port, an extracorporeal circuit, a vascular graft, a pump, a cardiovascular suture, a glove, a wound dressing, a table, and a medical implant.
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56. (canceled)
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58-59. -59. (canceled)
- 60. A method for preventing nosocomial infections in a subject comprising coating a medical device that the subject is required to use with a composition comprising a basic reagent and to a dye, wherein the device is selected from the group consisting of an endotracheal tube, a vascular catheter, a nephrostomy tube, a stent, an orthopedic device, a prosthetic valve, a urinary catheter, a peritoneal catheter, an eptidural catheter, a central nervous system catheter, a blood exchanging device, a vascular access port, an extracorporeal circuit, a vascular graft, a pump, a cardiovascular suture, a glove, a wound dressing, a table, and a medical implant.
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69-79. -79. (canceled)
- 88. A glove coated with a composition comprising brilliant green and a basic reagent, wherein the device is a glove.
Specification