Device and method for manipulating minute ventilation
2 Assignments
0 Petitions
Accused Products
Abstract
A stimulation device is provided that stimulates breathing to manipulate blood gas concentrations such as SaO2 or PCO2 and thereby treat underlying causes of breathing disorders and heart failure progression. A programmable device is provided for setting diaphragm stimulation waveforms that adjust minute ventilation about a predetermined baseline value. Normal breathing of the subject is observed to establish a baseline reference minute ventilation, and the device is programmed to produce stimulation waveforms that may provide either a decrease or an increase in the patients minute ventilation. The minute ventilation of the subject may be decreased or increased from the baseline level by decreasing or increasing a parameter that changes minute ventilators.
101 Citations
68 Claims
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1-25. -25. (canceled)
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26. A method of treating a cardiovascular disorder comprising:
stimulating tissue to elicit a diaphragm response to manipulate blood gas levels to thereby reduce a load on the heart.
- 27. The method of 26 wherein the stimulation is configured to elicit a diaphragm response to thereby increase SAO2 levels for a predetermined period of time.
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29. A method for treating a subject having a disorder characterized by a lower resting lung volume comprising:
stimulating tissue to elicit a diaphragm response to thereby increase volume during a non-inspiratory phase. - View Dependent Claims (30, 31)
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32. A diaphragm stimulation device for use with a ventilator:
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wherein the device is configured to stimulate tissue of a subject to elicit a diaphragm response; wherein the device comprises a sensor configured to sense diaphragm EMG and a device configured to sense diaphragm movement; and wherein the device is configured to turn off diaphragm stimulation when diaphragm movement is sensed in the absence of sensing a diaphragm EMG.
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33. A system for diaphragm stimulation to elicit a minute ventilation different from the normal respiratory minute ventilation, comprising:
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a programmable stimulation device for stimulating tissue of a subject to thereby elicit diaphragm response; a sensor configured to sense a respiration parameter corresponding to a normal minute ventilation; wherein said programmable stimulation device is programmable to provide a stimulation waveform to said diaphragm to elicit a minute ventilation different from the normal respiratory minute ventilation. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40)
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41. A method for providing a decreased minute ventilation in a subject with a programmable stimulation device coupled to tissue, said method comprising:
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observing a normal tidal volume and a normal respiratory rate of said subject; determining stimulation waveform parameters for producing a normal respiratory rate and a decreased tidal volume in said subject; storing said stimulation waveform parameters in said programmable device; and applying a waveform stimulus to said tissue to elicit a diaphragm response wherein said waveform stimulus is characterized by said stimulation waveform parameters.
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42. A method for providing an increased minute ventilation in a subject with a programmable stimulation device coupled to tissue of the subject, said method comprising:
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observing a normal tidal volume and a normal respiratory rate of said subject; determining stimulation waveform parameters for producing a normal respiratory rate and an increased tidal volume in said subject; storing said stimulation waveform parameters in said programmable device; and applying a waveform stimulus to said tissue to elicit a diaphragm response wherein said waveform stimulus is characterized by said stimulation waveform parameters.
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43. A method of respiration therapy comprising:
increasing minute ventilation with respect to a baseline minute ventilation by providing stimulation to elicit a diaphragm activation to increase one or more of a respiration rate, an inspiration duration, and a ratio of inspiration duration with respect to a corresponding respiration cycle duration.
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44. A method for providing a decreased minute ventilation in a subject with a programmable stimulation device coupled to a tissue of the subject, said method comprising:
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observing a normal tidal volume and a normal respiratory rate of said subject;
determining stimulation waveform parameters for producing a decreased respiratory rate and a normal tidal volume in said subject;storing said stimulation waveform parameters in said programmable device; and
applying a waveform stimulus to said tissue to elicit a diaphragm response, wherein said waveform stimulus is characterized by said stimulation waveform parameters.
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45. A method for establishing a baseline minute ventilation for a subject with an implanted programmable diaphragm stimulation device, said method comprising:
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attaching a flow sensor to said subject;
observing a normal tidal volume and a normal respiratory rate;measuring and storing data concerning the respiration of said subject; and
determining a normal inspiration duration. - View Dependent Claims (46, 47, 48, 49, 50)
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51. A respiration stimulation device to change minute ventilation with respect to a baseline minute ventilation comprising:
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at least one electrode configured to be coupled to tissue of a subject; a signal source coupled to the electrode and configured to deliver a stimulation signal to the tissue to control breathing; wherein the signal source is configured to control at least one parameter corresponding to minute ventilation to change minute ventilation with respect to a baseline minute ventilation. - View Dependent Claims (52, 53)
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54. A system for diaphragm stimulation to elicit a tidal volume different from a normal respiratory tidal volume, comprising:
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a programmable stimulation device for stimulating tissue of a subject to thereby elicit diaphragm response; a sensor configured to sense a respiration parameter corresponding to a normal tidal volume; wherein said programmable stimulation device is programmable to provide a stimulation waveform to said diaphragm to elicit a tidal volume different from a normal respiratory tidal volume sensed by said sensor. - View Dependent Claims (55, 56, 57, 58, 59, 60)
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61. A method of providing respiratory therapy comprising:
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providing an electrical stimulator configured to stimulate tissue to activate a portion of a diaphragm comprising; stimulating tissue during exhalation to activate at least a portion of a diaphragm in a manner that increases end expiratory lung volume.
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62. A method for treating a subject with a breathing disorder comprising the step of:
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electrically stimulating tissue of a patient to elicit a diaphragm response, wherein the step of electrically stimulating tissue comprises; electrically stimulating tissue of the subject during a non-inspiratory phase of a respiration cycle. - View Dependent Claims (63, 64, 65, 66, 67, 68)
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Specification