FIXATION TECHNOLOGY

• US 20080183300A1
• Filed: 02/26/2008
• Published: 07/31/2008
• Est. Priority Date: 12/03/1999
• Status: Abandoned Application

• Current Assignee: University of Leeds
• Original Assignee: University of Leeds
• Inventors: Toyoda, Takashi, Seedhom, Bahaa, Pullan, Michael
• Application Number:
  US12/037,662
• Publication Number:
  US 20080183300A1
• Time in Patent Office: Days
• US Class Current: 623/23.76
• CPC Class Codes: A61B 17/1604 Chisels; Rongeurs; Punches; Stamps
• CPC Class Codes: A61B 17/1637 Hollow drills or saws producing a curved cut, e.g. cylindrical A61B10/025, A61B17/1695 take precedence
• CPC Class Codes: A61B 17/1659 Surgical rasps, files, planes, or scrapers
• CPC Class Codes: A61B 17/1675 for the knee
• CPC Class Codes: A61B 17/32053 Punch like cutting instruments, e.g. using a cylindrical or oval knife A61B17/326 takes precedence; trepans A61B17/1695; for use on the cornea A61F9/007
• CPC Class Codes: A61B 2017/00464 for use with different instruments
• CPC Class Codes: A61B 2017/00469 for insertion of instruments, e.g. guide wire, optical fibre
• CPC Class Codes: A61B 2017/1602 Mills
• CPC Class Codes: A61B 2017/320004 abrasive
• CPC Class Codes: A61B 2017/320008 Scrapers
• CPC Class Codes: A61B 2017/320012 Brushes
• CPC Class Codes: A61B 2090/08021 of the patient or his organs
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/0095 Packages or dispensers for prostheses or other implants for intraocular lenses A61F2/1691; for dental surgery A61C19/02
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/2846 Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/4618 of cartilage
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues
• CPC Class Codes: A61F 2002/286 : Bone stimulation by mechanical vibrations for enhancing ossification
• CPC Class Codes: A61F 2002/30062 : (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30064 : Coating or prosthesis-covering structure made of biodegradable material
• CPC Class Codes: A61F 2002/30113 : circular
• CPC Class Codes: A61F 2002/30118 : concentric circles
• CPC Class Codes: A61F 2002/30125 : elliptical or oval
• CPC Class Codes: A61F 2002/30131 : horseshoe- or crescent- or C-shaped or U-shaped
• CPC Class Codes: A61F 2002/30143 : hexagonal
• CPC Class Codes: A61F 2002/30235 : tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30556 : for adjusting thickness
• CPC Class Codes: A61F 2002/30599 : stackable
• CPC Class Codes: A61F 2002/30604 : modular
• CPC Class Codes: A61F 2002/30677 : Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30716 : for single use, e.g. having means for preventing re-use
• CPC Class Codes: A61F 2002/30761 : Support means for artificial cartilage, e.g. cartilage defect covering membranes
• CPC Class Codes: A61F 2002/30762 : Means for culturing cartilage
• CPC Class Codes: A61F 2002/30764 : Cartilage harvest sites
• CPC Class Codes: A61F 2002/3093 : for promoting ingrowth of bone tissue
• CPC Class Codes: A61F 2002/3097 : using laser
• CPC Class Codes: A61F 2002/4635 : using minimally invasive surgery
• CPC Class Codes: A61F 2210/0004 : bioabsorbable
• CPC Class Codes: A61F 2230/0006 : circular
• CPC Class Codes: A61F 2230/0008 : elliptical or oval
• CPC Class Codes: A61F 2230/0013 : Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2230/0017 : Angular shapes
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2250/0009 : for adjusting thickness
• CPC Class Codes: A61F 2250/0063 : Nested prosthetic parts
• CPC Class Codes: A61F 2250/009 : for single use, e.g. having means for preventing re-use
• CPC Class Codes: A61F 2310/00341 : Coral, e.g. aragonite, porite
• CPC Class Codes: A61F 2310/00359 : Bone or bony tissue

Abstract

The invention relates to a method for the repair of damaged tissue present at or on the surface of bone in an animal, the method comprising forming a narrow groove around at least part of said damaged tissue, which groove extends into the bone below the damaged tissue, replacing the tissue around which the groove extends by at least one layer of biocompatible replacement material, and anchoring the material to the bone by the use of retaining means extending from the material into the groove; instruments for use in the repair of damaged tissue and kits comprising said instruments.

Claims

1. A replacement element for the repair of damaged tissue present at or on the surface of bone in an animal, including a human being, said element comprising:

a pad of bio-compatible material to provide a prosthetic scaffold for the growth of tissue and shaped and dimensioned to occupy a site from which the damaged tissue, or a part thereof, has been removed, the pad configured to allow migration of cells from surrounding tissue into the site;

characterised by;

a retaining sheet configured to retain the pad at the site, wherein the pad and the retaining sheet are manufactured from non-woven material.

2. The replacement element according to claim 1 wherein when the pad is positioned substantially centrally at the retaining sheet, the retaining sheet extends away from the pad by a distance at least equal to the edge to edge distance across the pad.

3. The replacement element according to claim 1 wherein the pad and retaining sheet are integral.

4. The replacement element according to claim 1 wherein at least a region of the pad and the retaining sheet are connected together.

5. The replacement element according to claim 1 wherein said bio-compatible material is tissue selected from cartilage, periosteum, bone, and synovium.

6. The replacement element according to claim 1 wherein said bio-compatible material is a synthetic bio-compatible sheet, fluid or gel.

7. The replacement element according to claim 1 forming part of a larger sheet of bio-compatible material which is located on a backing sheet, the pad being defined in the sheet and being readily removable therefrom.

8. The replacement element according to claim 7 wherein the larger sheet includes a covering layer.

9. The replacement element according to claim 1 wherein the replacement pad is in the form of a circular, crescent-shaped, ring shaped or part circular pad.

10. The replacement element according to claim 1, wherein the replacement pad is bio-absorbable and bioenhanced.

11. The replacement element according to claim 1, wherein the replacement pad is non-bioabsorbable and bioenhanced.

12. The replacement element according to claim 1, wherein the replacement pad is seeded with cells selected from chondrocyte, fibroblasts, mesenchymal progenitor cells, endosteal cells, periosteal cells, or inducible chondroprogenitor cells in extraskeletal organs.

13. The replacement element according to claim 12, wherein the cells are derived from tissue material removed from the site to be repaired.

14. The replacement element according to claim 12, wherein said seeded cells are genetically engineered.

15. The replacement element according to claim 1, wherein the retaining sheet is in the form of a thin, flexible mesh.

16. The replacement element according to claim 1, wherein the retaining sheet comprises woven fabric, or non-woven fabric, with holes for tissue and bone in growth.

17. The replacement element according to claim 1, wherein the retaining sheet comprises tissue.

18. The replacement element according to claim 17 wherein said tissue is selected from periosteum, synovium, fascia, or retinaculum.

19. The replacement element according to claim 1, wherein said replacement pad and said retaining sheet are non-integral.

20. A replacement kit for the repair of damaged tissue present at or on the surface of bone in an animal, the kit comprising at least one replacement element according to claim 1 wherein the retaining sheet is anchorable to the bone so as to retain the pad at the site from which damaged tissue has been removed, said retaining sheet being capable of anchoring location within a groove formed in the bone about said site.

21. The replacement kit according to claim 20 wherein the kit is sterile and disposable.