System and Method for Verifying the Contents of a Filled, Capped Pharmaceutical Prescription

• US 20080183410A1
• Filed: 01/11/2008
• Published: 07/31/2008
• Est. Priority Date: 01/12/2007
• Status: Active Grant

• Current Assignee: Parata Systems, LLC (Becton, Dickinson & Co), Lambda Solutions, Inc.
• Original Assignee: Lambda Solutions, Inc.
• Inventors: Townsend, W.L. Douglas, Eberdt, Jesse Samuel, Klein, Peter A., Zhou, Wang-Long, Sapirstein, Victor, Yang, Yongwu
• Granted Patent: US 7,898,657 B2
• Time in Patent Office: Days
• US Class Current: 702/82
• CPC Class Codes: G01N 21/65 Raman scattering
• CPC Class Codes: G01N 21/9508 Capsules; Tablets

Abstract

A probe for a system for determining the chemical signature of a pharmaceutical compound. The probe comprises: a housing; an inlet in the housing adapted to be connected to a transmitting optical fiber; a scanning aperture in the housing; a receiving outlet in the housing adapted to be connected to a receiving optical fiber; at least one transmission reflector positioned in the housing to receive laser light from the transmitting optical fiber and reflect the laser light through the detection outlet to a pharmaceutical vial containing a pharmaceutical compound positioned outside the housing, and at least one receiving reflector positioned in the housing to receive light reflected by the pharmaceutical compound and reflect the light to the receiving outlet. This configuration can enable rapid and accurate scanning of a pharmaceutical contained in a vial positioned adjacent the detection outlet.

Claims

1. A probe for a system for determining the chemical signature of a pharmaceutical compound, comprising:

a housing;

an inlet in the housing adapted to be connected to a transmitting optical fiber;

a scanning aperture in the housing;

a receiving outlet in the housing adapted to be connected to a receiving optical fiber;

at least one transmission reflector positioned in the housing to receive laser light from the transmitting optical fiber and reflect the laser light through the detection outlet to a pharmaceutical vial containing a pharmaceutical compound positioned outside the housing, and

at least one receiving reflector positioned in the housing to receive light reflected by the pharmaceutical compound and reflect the light to the receiving outlet.

2. The probe defined in claim 1, wherein the housing includes side walls, and wherein the inlet is located in a first side wall and the scanning aperture is located in a second side wall.

3. The probe defined in claim 2, wherein the receiving outlet is located in the first side wall.

4. The probe defined in claim 2, wherein the second side wall is generally normal to the first side wall.

5. The probe defined in claim 1, wherein the at least one transmission reflector is a plurality of transmission reflectors.

6. The probe defined in claim 5, wherein one of the plurality of transmission reflectors is positioned to reflect laser light directly at the pharmaceutical vial at an angle of between about 75 and 85 degrees relative to a bottom surface of the pharmaceutical vial.

7. The probe defined in claim 5, wherein the plurality of transmission reflectors includes at least three transmission reflectors.

8. The probe defined in claim 5, wherein the plurality of transmission reflectors includes five transmission reflectors.

9. The probe defined in claim 1, further including a lens positioned to focus laser light transmitted between the inlet and the at least one reflector.

10. The probe defined in claim 1, wherein the at least one receiving reflector is a plurality of receiving reflectors.

11. The probe defined in claim 10, wherein one of the plurality of receiving reflectors positioned to receive light reflected from the pharmaceutical at an angle of between about 75 and 85 degrees relative to a bottom surface of the pharmaceutical vial.

12. The probe defined in claim 11, further comprising a lens located between one of the plurality of receiving reflectors and the receiving outlet, the lens configured to focus the reflected light as it passes through the receiving outlet.

13. The probe defined in claim 1, wherein the at least one transmission reflector is a plurality of transmission reflectors, and wherein the at least one receiving reflector is a plurality of receiving reflectors, and wherein at least one reflector serves as both a transmission reflector and a receiving reflector.

14. A system for determining the chemical signature of a pharmaceutical compound in a vial, comprising:

a stage configured to receive and hold a pharmaceutical vial;

a spectrometer;

a fiber optic bundle connected to the spectrometer, the fiber optic bundle including a transmitting optical fiber and a receiving optical fiber; and

a probe comprising;

a housing;

an inlet in the housing connected to the transmitting optical fiber;

a detection outlet in the housing, the detection outlet positioned adjacent the stage;

a receiving outlet in the housing connected to the receiving optical fiber;

at least one transmission reflector positioned in the housing to receive laser light from the transmitting optical fiber and reflect the laser light through the detection outlet to a pharmaceutical compound in a pharmaceutical vial positioned on the stage; and

at least one receiving reflector positioned in the housing to receive light reflected by the pharmaceutical compound and reflect the light to the receiving optical fiber; and

a processor for processing optical signals from the pharmaceutical compound and comparing the processed signals with at least one spectrum from a database of known pharmaceutical compounds.

15. The system defined in claim 14, further comprising a stamping device configured to indicate that a pharmaceutical vial has been approved.

16. The system defined in claim 14, further comprising structure for separating rejected vials from approved vials.

17. The system defined in claim 14, further comprising a bar code scanner positioned to scan a bar code on the pharmaceutical vial as it is positioned on the stage.

18. A method of verifying pharmaceuticals contained in a pharmaceutical vial, comprising:

positioning a pharmaceutical vial containing a pharmaceutical adjacent a verification system;

passing laser light along a transmission path from a laser generator to the pharmaceutical in the vial, the transmission path including at least one redirection of the laser light with a reflector;

passing light reflected by the pharmaceutical along a receiving path from the pharmaceutical to a detector, the receiving path including at least one redirection of the light with a reflector;

determining the chemical signature of the pharmaceutical based on the reflected light;

determining a prescribed pharmaceutical for the vial based on a label affixed to the vial; and

comparing the determined chemical signature against a database of known chemical signatures to determine whether the pharmaceutical contained in the vial is the prescribed pharmaceutical for the vial.

19. The method defined in claim 18, wherein the step of determining the prescribed pharmaceutical for the vial comprises scanning indicia on the label affixed to the vial, the indicia indicating the prescribed pharmaceutical.

20. The method defined in claim 18, wherein the step of passing laser light comprises passing a beam of laser light that has a diameter of between about 2.5 and 3.5 mm as the light reaches the vial.

21. The method defined in claim 18, further comprising the step of stamping the label affixed to the vial if the pharmaceutical in the vial matches the prescribed pharmaceutical.

22. The method defined in claim 18, wherein the vial has a flat bottom surface, and wherein the laser light is directed to the vial at an angle of between about 75 and 85 degrees relative to the vial bottom surface.

23. The method defined in claim 18, wherein the step of determining the chemical signature is performed with Raman spectroscopy.

24. The method defined in claim 18, wherein the wavelength of the laser light is less than about 140 cm⁻

1.

25. The method defined in claim 18, wherein an initial segment of the transmission path defines a first direction, and wherein an initial segment of the receiving path defines a second direction, and wherein the first and second directions are generally perpendicular.