Disposable monolithic column
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Abstract
Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.
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Citations
81 Claims
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1-55. -55. (canceled)
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56. A chromatographic system comprising:
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(a) a sample injector; (b) at least one chromatographic column having a column casing and at least one permeable monolithic polymeric plug inside the column casing positioned to receive a sample from the sample injector; (c) a solvent reservoir in communication with the chromatographic column for supplying a solvent to the at least one column; (d) said column casing including a column casing wall with an internal column casing surface; and (e) said at least one permeable monolithic polymeric plug having smooth walls without discontinuities in contact with an internal surface of the column casing wall. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65)
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66. A separating system comprising:
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(a) a permeable size-compensated polymeric support; (b) a sample injector positioned to inject sample onto the permeable size-compensated polymer support; (c) a solvent reservoir in communication with the support of permeable size-compensated polymer; and (d) a detector positioned to receive fluid from said permeable size-compensated polymeric support.
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67. A method of controlling polymerization of a monolithic polymer plug suitable for use in a separating device comprising the steps of:
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(a) establishing a polymerization mixture including a monomer and a porogen; (b) applying radiation to the polymerization mixture to input energy through the mixture to polymerize the polymerization mixture to form a monolithic polymer plug; and (c) washing out the porogen. - View Dependent Claims (68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80)
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81. A method of polymerizing a mixture to form a solid support suitable for use in a separating device containing at least one monomer and a porogen comprising the step of irradiating the mixture with x-rays during polymerization to form a monolithic polymer plug.
Specification