SILANE-TREATED SILICA FILTER MEDIA

• US 20080185333A1
• Filed: 04/11/2008
• Published: 08/07/2008
• Est. Priority Date: 10/01/2002
• Status: Active Grant

• Current Assignee: Dow Corning Corporation (Dow, Inc.)
• Original Assignee: Dow Corning Corporation (Dow, Inc.)
• Inventors: Steele, Landon M., Heng, Meng H., Gibson, Gary L., Revis, Anthony, Lane, Thomas H., Kollar, Csilla, Hayes, Keith
• Granted Patent: US 7,850,012 B2
• Time in Patent Office: Days
• US Class Current: 210/508
• CPC Class Codes: B01D 15/361 Ion-exchange
• CPC Class Codes: B01D 15/3804 Affinity chromatography
• CPC Class Codes: B01J 20/103 comprising silica
• CPC Class Codes: B01J 20/14 Diatomaceous earth
• CPC Class Codes: B01J 20/286 Phases chemically bonded to a substrate, e.g. to silica or to polymers
• CPC Class Codes: B01J 20/3204 Inorganic carriers, supports or substrates
• CPC Class Codes: B01J 20/3242 Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
• CPC Class Codes: B01J 20/3244 Non-macromolecular compounds
• CPC Class Codes: B01J 20/3257 the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
• CPC Class Codes: B01J 20/3259 comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom
• CPC Class Codes: B01J 2220/4887 Residues, wastes, e.g. garbage, municipal or industrial sludges, compost, animal manure; fly-ashes
• CPC Class Codes: Y10T 436/25375 Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Abstract

The present invention provides methods for separating one or more components of interest from a sample containing particulates and soluble materials. The method comprises the steps of: (a) filtering a sample through silica filter media whose surface silanol groups have reacted with one or more silanes, and (b) simultaneously capturing particulates and binding a soluble component to the silica filter media. The bound soluble component of interest is subsequently eluted from the silica filter media. In one embodiment of the invention, unwanted soluble materials are captured by the treated silica filter media and desired component of interest is recovered from the flow-through. In another embodiment, different components of interest are recovered from both the eluate and the flow-through. Preferred treated silica filter media are silane-treated rice hull ash or diatomaceous earth with functional quarternary ammonium group or functional sulphonate group. The present invention also provides silane-treated silica filter media.

Claims

1. Silane-treated silica filter media prepared by reacting the surface active group of silica filter media with one or more silanes comprising a hydrolyzable moiety selected from the group consisting of aryloxy, amide, methacrylate, carbonyl, urethane, pyrrole, carboxy, cyano, aminoacyl, acylamino, alkyl ester, and aryl ester, wherein the silica filter media are rice hull ash, oat hull ash or diamataceous earth.

2. The silane-treated silica filter media according to claim 1, wherein said hydrolyzable moiety is selected from the group consisting of aryloxy, amide, methacrylate, carbonyl, urethane, pyrrole, and cyano.

3. The silane-treated silica filter media according to claim 1, wherein said silane has an additional functional moiety selected from the group consisting of quaternary ammonium, aryl, amino, urea, methacrylate, imidazole, carbonyl, isothiorium, sulfonate and phosphonate.

4. Silane-treated silica filter media prepared by reacting the surface active group of silica filter media with silanes selected from the group consisting of 3-aminopropyltrimethoxysilane and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

3-trihydrosilylpropylmethylphosphonate, sodium salt and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

N-trimethoxysilylpropyl-N,N,N—

Cl, trimethylammonium chloride and (3-glycidoxypropyl)trimethoxysilane;

3-trihydrosilylpropylmethylphosphonate, sodium salt and bis-(2-hydroxyethyl)-3-aminopropyltriethoxysilane;

3-(N-styrylmethyl-2-aminoethylamino)-propyltrimethoxysilane hydrochloride and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

2-(trimethoxysilylethyl)pyridine and N-(3-triethoxysilylpropyl)-gluconamide;

N-trimethoxysilylpropyl-N,N,N—

Cl, trimethylammonium chloride and N-(3-triethoxysilylpropyl)-gluconamide;

N-trimethoxysilylpropyl-N,N,N—

Cl, trimethylammonium chloride and 2-hydroxy-4-(3-triethoxysilylpropoxy)-diphenylketone;

3-mercaptopropyltriethoxysilane and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

3-(triethoxysilyl)propylsuccinic anhydride and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

trimethoxysilylpropyl-ethylenediamine, triacetic acid, trisodium salt and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

2-(4-chlorosulfonylphenyl)-ethyltrichlorosilane and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane; and

2-(4-chlorosulfonylphenyl)-ethyltrichlorosilane and bis-(2-hydroxyethyl)-3-aminopropyltriethoxysilane, wherein the silica filter media are rice hull ash, oat hull ash or diamataceous earth.

5. Silane-treated silica filter media prepared by reacting the surface active group of silica filter media with one or more silanes selected from the group consisting of:

3-(trimethoxysilyl)-2-(p,m-chloromethyl)-phenylethane, 2-hydroxy-4-(3-triethoxysilylpropoxy)-diphenylketone, (chloromethyl)phenylethyl)trimethoxysilane, phenyldimethylethoxysilane, N-(2-aminoethyl)-3-aminopropyltrimethoxysilane, 2-(trimethoxysilylethyl)pyridine, N-(3-trimethoxysilylpropyl)pyrrole, trimethoxysilylpropyl polyethyleneimine, N-(3-trimethoxysilylpropyl)pyrrole, bis(2-hydroxyethyl)-3-aminopropyltriethoxysilane, N-(triethoxysilylpropyl)-O-polyethylene oxide urethane, N-(triethoxysilylpropyl)urea, 3-(trimethoxysilyl)propyl methacrylate, 3-(triethoxysilyl)propylsuccinic anhydride, tris(3-trimethoxysilylpropyl)isocyanurate, bis[(3-methyldimethoxysilyl)propyl]-polypropylene oxide, N-(triethoxysilylpropyl)-O-polyethylene oxide urethane, 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane, N-[3-(triethoxysilyl)propyl]imidazole, N-(3-triethoxysilylpropyl)-4,5-dihydroimidazole, 2-(4-chlorosulfonylphenyl)-ethyltrichlorosilane, trimethoxysilylpropylisothiouronium chloride, N-(3-triethoxysilylpropyl)-gluconamide, N-(triethoxysilylpropyl)-4-hydroxybutyramide, N-(triethoxysilylpropyl)-O-polyethylene oxide urethane, O-(propargyloxy)-N-(triethoxysilylpropyl)urethane, 3-(trimethoxysilyl)propyl-ethylenediamine triacetic acid trisodium salt, and 3-(trihydroxysilyl)propylmethylposphonate sodium salt, wherein the silica filter media are rice hull ash, oat hull ash, or diamataceous earth.

6. The silane-treated silica filter media of claim 5, where said one or more silanes are 3-(trimethoxysilyl)-2-(p,m-chloromethyl)-phenylethane, phenyldimethylethoxysilane, N-(2-aminoethyl)-3-aminopropyltrimethoxysilane, bis(2-hydroxyethyl)-3-aminopropyltriethoxysilane, N-(triethoxysilylpropyl)urea, 3-(trimethoxysilyl)propyl methacrylate, or N-(3-triethoxysilylpropyl)-4,5-dihydroimidazole.