SYSTEM WITH EXTENDED RANGE OF MOLECULAR SENSING THROUGH INTEGRATED MULTI-MODAL DATA ACQUISITION
First Claim
1. A multi-modal data acquisition system for detecting target material on a biological reaction surface, the data acquisition system comprising:
- a radiation source for generating an incoming beam to illuminate the biological reaction surface, the incoming beam impinging on the biological reaction surface at an oblique incidence angle and producing a reflected beam, the reflected beam being produced by the incoming beam reflecting off the biological reaction surface;
an interferometric detector for detecting an interferometric signal from the illuminated biological reaction surface, the reflected beam being directed to the interferometric detector,a fluorescence detector for detecting a fluorescence signal from the illuminated biological reaction surface;
the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam on the fluorescence detector; and
a processing system for receiving the interferometric signal and the fluorescence signal and determining the presence or absence of the target material on the biological reaction surface.
1 Assignment
0 Petitions
Accused Products
Abstract
A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.
-
Citations
8 Claims
-
1. A multi-modal data acquisition system for detecting target material on a biological reaction surface, the data acquisition system comprising:
-
a radiation source for generating an incoming beam to illuminate the biological reaction surface, the incoming beam impinging on the biological reaction surface at an oblique incidence angle and producing a reflected beam, the reflected beam being produced by the incoming beam reflecting off the biological reaction surface; an interferometric detector for detecting an interferometric signal from the illuminated biological reaction surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated biological reaction surface;
the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam on the fluorescence detector; anda processing system for receiving the interferometric signal and the fluorescence signal and determining the presence or absence of the target material on the biological reaction surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
-
Specification