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SYSTEM WITH EXTENDED RANGE OF MOLECULAR SENSING THROUGH INTEGRATED MULTI-MODAL DATA ACQUISITION

  • US 20080186477A1
  • Filed: 01/22/2008
  • Published: 08/07/2008
  • Est. Priority Date: 01/19/2007
  • Status: Active Grant
First Claim
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1. A multi-modal data acquisition system for detecting target material on a biological reaction surface, the data acquisition system comprising:

  • a radiation source for generating an incoming beam to illuminate the biological reaction surface, the incoming beam impinging on the biological reaction surface at an oblique incidence angle and producing a reflected beam, the reflected beam being produced by the incoming beam reflecting off the biological reaction surface;

    an interferometric detector for detecting an interferometric signal from the illuminated biological reaction surface, the reflected beam being directed to the interferometric detector,a fluorescence detector for detecting a fluorescence signal from the illuminated biological reaction surface;

    the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam on the fluorescence detector; and

    a processing system for receiving the interferometric signal and the fluorescence signal and determining the presence or absence of the target material on the biological reaction surface.

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