Biomarkers of Cancer Risk and Their Use in Cancer Detection and Prevention
First Claim
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1. A method for identifying a subject that has cancer, or is at an elevated risk for developing cancer, comprising determining the ratio of depurinating estrogen-DNA adducts to their respective metabolites and conjugates in a biological sample from the subject, wherein an increased level of the ratio, as compared to a control, indicates that the subject has cancer, or is at an elevated risk for developing cancer.
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Abstract
Certain embodiments of the present invention provide methods for identifying subjects that have, or are at risk for developing, cancer and for determining the effectiveness of preventive cancer treatments.
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20 Claims
- 1. A method for identifying a subject that has cancer, or is at an elevated risk for developing cancer, comprising determining the ratio of depurinating estrogen-DNA adducts to their respective metabolites and conjugates in a biological sample from the subject, wherein an increased level of the ratio, as compared to a control, indicates that the subject has cancer, or is at an elevated risk for developing cancer.
- 12. A method for determining the effectiveness of a preventive cancer treatment, comprising determining the ratio of depurinating estrogen-DNA adducts to their respective metabolites and conjugates in a biological sample from the subject before and after a preventive cancer treatment, wherein a decrease in the level of the ratio after treatment indicates that the cancer treatment is effective to reduce the risk of cancer.
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