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Methods and compositions for modification of the human glucocorticoid receptor locus

  • US 20080188000A1
  • Filed: 11/13/2007
  • Published: 08/07/2008
  • Est. Priority Date: 11/13/2006
  • Status: Active Grant
First Claim
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1. A method for inactivating glucocorticoid receptor (GR) function in a cell, the method comprising:

  • expressing in the cell a pair of fusion proteins, wherein each fusion protein comprises;

    (i) a zinc finger DNA-binding domain that has been engineered to bind a target sequence in a GR gene, and(ii) a cleavage half-domain;

    such that the fusion proteins catalyze a double-strand break in the GR gene.

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