OPTICAL SYSTEMS AND METHODS FOR RATIOMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION
First Claim
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1. An optical device for determining blood glucose concentration, comprising:
- an excitation light source that emits an excitation light signal;
a fiber optic sensor sized to be positioned within a blood vessel, the sensor being optically coupled to the excitation light source and comprising an indicator system comprising a fluorophore operably coupled to a glucose binding moiety, wherein upon absorption of at least a portion of the excitation light signal, the indicator system emits an emission light signal having an intensity related to the blood glucose concentration; and
a light sensitive module operably coupled to at least the fiber optic sensor, wherein the light sensitive module detects the emission light signal and at least a second light signal, wherein the second light signal is derived from the excitation light source or an optional reference light source.
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Abstract
Novel optical devices, methods and systems relating to the detection of glucose, and more particularly to real-time glucose monitoring, are disclosed herein. More particularly, various hardware and methodological means are disclosed for ratiometric correction of optical glucose measurements for artifacts of optical systems.
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Citations
40 Claims
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1. An optical device for determining blood glucose concentration, comprising:
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an excitation light source that emits an excitation light signal; a fiber optic sensor sized to be positioned within a blood vessel, the sensor being optically coupled to the excitation light source and comprising an indicator system comprising a fluorophore operably coupled to a glucose binding moiety, wherein upon absorption of at least a portion of the excitation light signal, the indicator system emits an emission light signal having an intensity related to the blood glucose concentration; and a light sensitive module operably coupled to at least the fiber optic sensor, wherein the light sensitive module detects the emission light signal and at least a second light signal, wherein the second light signal is derived from the excitation light source or an optional reference light source. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24)
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20. An optical device for determining blood glucose concentration, comprising:
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an excitation light source that emits an excitation light signal; a fiber optic sensor sized to be positioned within a blood vessel, the sensor being optically coupled to the excitation light source and comprising an indicator system comprising a fluorophore operably coupled to a glucose binding moiety, wherein upon absorption of at least a portion of the excitation light signal, the indicator system emits an emission light signal having an intensity related to the blood glucose concentration; and a detector system operably coupled to at least the sensor, wherein the detector system comprises a means for detecting the emission light signal and at least a second light signal, wherein the second light signal is derived from the excitation light source or an optional reference light source. - View Dependent Claims (21, 22, 23)
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25. An optical system for determining blood glucose concentration, comprising:
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an excitation light source that emits an excitation light signal; a fiber optic sensor sized to be positioned within a blood vessel, the sensor being optically coupled to the excitation light source and comprising an indicator system comprising a fluorophore operably coupled to a glucose binding moiety, wherein upon absorption of at least a portion of the excitation light signal, the indicator system emits an emission light signal having an intensity related to the blood glucose concentration; at least one optical module configured to deliver the excitation light signal to the fiber optic sensor and the emission light signal from the fiber optic sensor to a detector system, wherein the detector system comprises a means for detecting the emission light signal and at least a second light signal, wherein the second light signal is derived from the excitation light source or an optional reference light source; and a computer system configured to receive data from the detector system, wherein the computer system is configured to perform ratiometric calculations on the data to substantially eliminate optical artifacts unrelated to glucose concentrations, wherein the computer system comprises a monitor for outputting data to a user, an input device for allowing the user to input additional data into the computer system, a processor for performing the ratiometric calculations, a storage device for storing data, and a memory. - View Dependent Claims (26, 27)
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28. A disposable fiber optic glucose sensor, comprising an elongate member having proximal and distal end regions,
wherein the proximal end region of the elongate member is configured for optically coupling to an optical device comprising an excitation light source and a detector, and wherein the distal end region of the elongate member is sized to be positioned within a blood vessel and comprises a cavity disposed therein and a reflective surface, wherein the cavity houses an indicator system comprising a fluorophore operably coupled to a glucose binding moiety immobilized within a hydrogel which is permeable to glucose in the blood vessel, such that upon excitation with an excitation light signal from the excitation light source, the indicator system emits an emission light signal having an intensity related to a blood glucose concentration.
Specification