BIOLOGICAL OPTICAL MEASUREMENT INSTRUMENT

• US 20080188729A1
• Filed: 01/15/2008
• Published: 08/07/2008
• Est. Priority Date: 01/17/2007
• Status: Active Grant

• Current Assignee: Hitachi, Ltd.
• Original Assignee: Hitachi, Ltd.
• Inventors: Sato, Hiroki, Maki, Atsushi, Obata, Akiko, Moda, Ichiro, Yasuhara, Takaomi, Ozaki, Kazutaka
• Granted Patent: US 8,521,243 B2
• Time in Patent Office: Days
• US Class Current: 600/340
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/381 Olfactory or gustatory stimuli
• CPC Class Codes: A61B 5/4011 Evaluating olfaction, i.e. sense of smell
• CPC Class Codes: A61B 5/4017 Evaluating sense of taste
• CPC Class Codes: A61B 5/486 Bio-feedback A61B5/375 takes precedence

Abstract

Appropriate measurement and analysis parameters are set according to cerebral function to be measured. To measure gustatory function, a time period of absence of cerebral activity to be measured is set so as not to contain a period of 60 seconds after start of stimulation, an activity period for analysis for an oxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 16 seconds, and an instant after a lapse of 25 seconds, after the start of the stimulation, and an activity period for analysis for a deoxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 28 seconds and an instant after a lapse of 37 seconds after the start of the stimulation. Moreover, a time interval between stimulations is set to 80 seconds or more.

Claims

1. A biological optical measurement instrument, comprising:

a light irradiation means for irradiating the head of a subject with light;

a light detection means for detecting transmitted light that is emitted from the light irradiation means, and that passes through a point of measurement in the head of the subject;

an input unit where the type of cerebral function to be measured is inputted;

a calculator that sets different analysis parameters according to the type of cerebral function inputted through the input unit, and that calculates an oxyhemoglobin concentration change signal and a deoxyhemoglobin concentration change signal at the point of measurement, on the basis of a signal detected by the light detection means; and

a display unit that displays the result of calculation by the calculator.

2. The biological optical measurement instrument according to claim 1, wherein the analysis parameters include a time parameter based on which a time period of absence of cerebral activity to be measured is set.

3. The biological optical measurement instrument according to claim 2, wherein

when the cerebral function to be measured is gustatory function, the time period of absence of cerebral activity to be measured is set based on time elapsed after start of stimulation, and

when the cerebral function to be measured is anything other than the gustatory function, the time period of absence of cerebral activity to be measured is set based on the time elapsed after the start of the stimulation and time elapsed after completion of the stimulation.

4. The biological optical measurement instrument according to claim 2, wherein

when the cerebral function to be measured is the gustatory function, the time period of absence of cerebral activity to be measured is set so as not to contain a period of 60 seconds after start of stimulation, and

when the cerebral function to be measured is anything other than the gustatory function, the time period of absence of cerebral activity to be measured is set so as not to contain a stimulation period and a period of 5 seconds after the completion of the stimulation.

5. The biological optical measurement instrument according to claim 1, wherein the analysis parameters include an activity period for analysis, which is a period for evaluation of the presence or absence of the cerebral activity, and if any, the intensity thereof.

6. The biological optical measurement instrument according to claim 5, wherein if the cerebral function to be measured is the gustatory function, the activity period for analysis for the oxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 16 seconds, and an instant after a lapse of 25 seconds, after start of stimulation, while the activity period for analysis for the deoxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 28 seconds, and an instant after a lapse of 37 seconds after the start of the stimulation.

7. The biological optical measurement instrument according to claim 5, wherein any one of an average value and a maximum value of any of the oxyhemoglobin concentration change signal and the deoxyhemoglobin concentration change signal measured during the activity period for analysis is used to evaluate the presence or absence of the cerebral activity, and if any, the intensity thereof.

8. The biological optical measurement instrument according to claim 1, wherein the analysis parameters include reference waveform data on the cerebral activity, for evaluation of the presence or absence of the cerebral activity, and if any, the intensity thereof.

9. The biological optical measurement instrument according to claim 8, wherein if the cerebral function to be measured is the gustatory function, the reference waveform data on the activity for the oxyhemoglobin concentration change signal is a polynomial function having a maximum value in the period between the instant after a lapse of 16 seconds, and the instant after a lapse of 25 seconds, after start of stimulation, while the reference waveform data on the activity for the deoxyhemoglobin concentration change signal is a polynomial function having a minimum value in the period between the instant after a lapse of 28 seconds, and the instant after a lapse of 37 seconds, after the start of the stimulation.

10. The biological optical measurement instrument according to claim 8, wherein the analysis parameters are prestored in a storage unit.

11. A biological optical measurement instrument, comprising:

a light irradiation means for irradiating the head of a subject with light;

a light detection means for detecting transmitted light that is emitted from the light irradiation means, and that passes through a point of measurement in the head of the subject;

an input unit where the type of cerebral function to be measured is inputted;

a calculator that calculates an oxyhemoglobin concentration change signal and a deoxyhemoglobin concentration change signal measured at the point of measurement, on the basis of a signal detected by the light detection means; and

a display unit that displays measurement parameters including a stimulation method and the result of calculation by the calculator,

wherein the measurement parameters varying according to the type of cerebral function inputted through the input unit are displayed on the display unit.

12. The biological optical measurement instrument according to claim 11, wherein if the cerebral function to be measured is gustatory function, a time interval of 80 seconds or more between stimulations is displayed as one of the measurement parameters.

13. The biological optical measurement instrument according to claim 11, wherein the measurement parameters are prestored in a storage unit.

14. A biological optical measurement instrument, comprising:

a light irradiation means for irradiating a subject with light;

a light detection means for detecting transmitted light that is emitted from the light irradiation means, and that passes through a point of measurement in the subject;

an input unit where the type of physiological change to be measured is inputted;

a calculator that sets different analysis parameters according to the type of physiological change inputted through the input unit, and that calculates an oxyhemoglobin concentration change signal and a deoxyhemoglobin concentration change signal at the point of measurement, on the basis of a signal detected by the light detection means; and

a display unit that displays the result of calculation by the calculator.

15. The biological optical measurement instrument according to claim 14, wherein the analysis parameters include a time parameter based on which a time period of absence of physiological change to be measured is set.

16. The biological optical measurement instrument according to claim 15, wherein when the physiological change to be measured is salivary gland function, the time period of absence of physiological change to be measured is set based on time elapsed after start of stimulation.

17. The biological optical measurement instrument according to claim 15, wherein when the physiological change to be measured is the salivary gland function, the time period of absence of physiological change to be measured is set so as not to contain a period of 60 seconds after start of stimulation.

18. The biological optical measurement instrument according to claim 14, wherein the analysis parameters include an activity period for analysis, which is a period for evaluation of the presence or absence of the physiological change, and if any, the intensity thereof.

19. The biological optical measurement instrument according to claim 18, wherein if the physiological change to be measured is the salivary gland function, the activity period for analysis for the oxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 16 seconds, and an instant after a lapse of 25 seconds, after start of stimulation, while the activity period for analysis for the deoxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 28 seconds, and an instant after a lapse of 37 seconds, after the start of the stimulation.

20. The biological optical measurement instrument according to claim 18, wherein any one of an average value and a maximum value of any of the oxyhemoglobin concentration change signal and the deoxyhemoglobin concentration change signal measured during the activity period for analysis is used to evaluate the presence or absence of the physiological change, and if any, the intensity thereof.

21. The biological optical measurement instrument according to claim 14, wherein the analysis parameters include reference waveform data on the physiological change, for evaluation of the presence or absence of the physiological change, and if any, the intensity thereof.

22. The biological optical measurement instrument according to claim 21, wherein if the physiological change to be measured is the salivary gland function, the reference waveform data on the activity for the oxyhemoglobin concentration change signal is a polynomial function having a maximum value in the period between the instant after a lapse of 16 seconds, and the instant after a lapse of 25 seconds, after start of stimulation, while the reference waveform data on the activity for the deoxyhemoglobin concentration change signal is a polynomial function having a minimum value in the period between the instant after a lapse of 28 seconds, and the instant after a lapse of 37 seconds, after the start of the stimulation.

23. The biological optical measurement instrument according to claim 21, wherein the analysis parameters are prestored in a storage unit.

24. A biological optical measurement instrument, comprising:

a light irradiation means for irradiating a subject with light;

a light detection means for detecting transmitted light that is emitted from the light irradiation means, and that passes through a point of measurement in the subject;

an input unit where the type of physiological change to be measured is inputted;

a calculator that calculates an oxyhemoglobin concentration change signal and a deoxyhemoglobin concentration change signal measured at the point of measurement, on the basis of a signal detected by the light detection means; and

a display unit that displays measurement parameters including a stimulation method and the result of calculation by the calculator,

wherein the measurement parameters varying according to the type of physiological change inputted through the input unit are displayed on the display unit.

25. The biological optical measurement instrument according to claim 24, wherein if the physiological change to be measured is salivary gland function, a time interval of 80 seconds or more between stimulations is displayed as one of the measurement parameters.

26. The biological optical measurement instrument according to claim 24, wherein the measurement parameters are prestored in a storage unit.