Active iontophoresis delivery system
First Claim
1. An active transdermal medicament patch comprising:
- (a) a flexible, planar biocompatible substrate having a therapeutic face on one side thereof configured for disposition against the skin of a patient;
(b) a medicament reservoir positioned on said therapeutic face of said substrate, said reservoir electrically conductively engaging the skin of a patient when said therapeutic face of said substrate is disposed there against;
(c) a power source carried on said substrate;
(d) current means non-removably carried on said substrate and driven by said power source for causing a substantially constant current through said reservoir and the skin of a patient during the course of a predetermined therapy period; and
(e) control means non-removably carried on said substrate for disabling said current means following functioning of said current means for said therapy period.
2 Assignments
0 Petitions
Accused Products
Abstract
A fully integrated, independently accurately performing, active transdermal medicament patch includes a flexible substrate with an adhesive-coated therapeutic face carrying a medicament reservoir. A circuit non-removably carried on the substrate and driven by a light-weight power source causes a substantially constant current to flow for a predetermined therapy period through the reservoir and the skin against which the therapeutic face is disposed. Net electrical polarity of the medicament determines the interconnection of circuit and power source to skin. The circuit includes a field effect transistor or an operational amplifier with a zener diode or a voltage regulator. A timer non-removably carried on the substrate disables the circuit following functioning the therapy period. An active transdermal medicament delivery system employs a single patch or pair of patches physically and electrically connected by a distensible tether.
124 Citations
84 Claims
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1. An active transdermal medicament patch comprising:
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(a) a flexible, planar biocompatible substrate having a therapeutic face on one side thereof configured for disposition against the skin of a patient; (b) a medicament reservoir positioned on said therapeutic face of said substrate, said reservoir electrically conductively engaging the skin of a patient when said therapeutic face of said substrate is disposed there against; (c) a power source carried on said substrate; (d) current means non-removably carried on said substrate and driven by said power source for causing a substantially constant current through said reservoir and the skin of a patient during the course of a predetermined therapy period; and (e) control means non-removably carried on said substrate for disabling said current means following functioning of said current means for said therapy period. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 61)
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19-27. -27. (canceled)
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60. (canceled)
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62-69. -69. (canceled)
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70. An active transdermal medicament patch comprising:
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(a) a flexible, planar biocompatible substrate having a therapeutic face on one side thereof configured for disposition against the skin of a patient; (b) a medicament reservoir positioned on said therapeutic face of said substrate said reservoir electrically conductively enaaging the skin of a patient when said therapeutic face of said substrate is disposed there against; (c) a power source carried on said substrate; and (d) an electric circuit non-removably carried on said substrate, said electric circuit being driven by said power source and being series-connected with said reservoir and the skin of a patient when said therapeutic face of said substrate is disposed there against, said electrical circuit thereby delivering a substantially constant current through said reservoir and the skin of the patient. - View Dependent Claims (71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
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Specification