Automatic Injection Device For Two-Chamber Ampoules

• US 20080188798A1
• Filed: 08/31/2006
• Published: 08/07/2008
• Est. Priority Date: 09/22/2005
• Status: Active Grant

• Current Assignee: Bayer Intellectual Property GmbH (Bayer AG)
• Original Assignee: Bayer Schering Pharma AG (Bayer AG)
• Inventors: Weber, Wilfried
• Granted Patent: US 7,678,072 B2
• Time in Patent Office: Days
• US Class Current: 604/82
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/31555 by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/31578 based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
• CPC Class Codes: A61M 5/31591 Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

An injection device for holding and activating a two-chamber ampulla has components whose relative movement causes the pistons of the two-chamber ampulla to be moved in order to mix the substances, as well as devices for injecting the product which is mixed in this way. For this purpose, a receptacle (103) into which the two-chamber ampulla (111) can be inserted and secured is held in a housing (101), and the receptacle (103) can be displaced by means of a carriage (108). A tappet (104) which acts on the pistons (111A, 111B) is movably held in the receptacle (103). A traction cable (114) which is deflected by means of a roller (109) which is mounted on the carriage (108) and one of whose ends is connected to the receptacle (103) and the other end of which is connected to a tension spring (110) which is held on the housing (101) is provided in order to carry out a mixing stroke, insertion stroke, injection stroke and a return stroke. Devices which can be activated automatically and/or manually between the housing (101), receptacle (103), tappet (104) and carriage (108) control their alternating coupling to the traction cable (114) and thus the sequence of the mixing stroke, insertion stroke, injection stroke and return stroke. The invention thus provides a partially automatic injection device for two-chamber ampullas whose handling comfort and safety for the patient are substantially improved.

Claims

1. An injection device for holding and activating a two-chamber ampoule, incorporating an injection needle and incorporating components whose relative movement causes the pistons of the two-chamber ampoule (111) to be displaced in order to mix the substances until the inner piston (111A) reaches the overflow channel (111E) of the two-chamber ampoule and comes to a standstill, whereupon the outer piston (111B) transports the first active substance, which is contained in the rear chamber (111D), into the front chamber (111C) leading to the injection needle and containing the second active substance, and also incorporating devices for injecting the product that has been mixed in this way,

characterized in that a receptacle (103), into which the two-chamber ampoule (111) is insertable and in which it is securable is held in a housing (101), that the receptacle (103) is displaceable by means of a cradle (108), that a tappet (104), which actuates the pistons (111A, 111B) is held displaceable in the receptacle (103), and that for performing the mixing stroke, needle-insertion stroke, injection stroke, and a return stroke, a traction cable (114) is provided, which is deflected by means of a roller (109), which is mounted on the cradle (108), and one of whose ends is connected to the receptacle (103) and the other end of which is connected to a tension spring (110), which is held on the housing (101), wherein devices, which are activated automatically and/or manually between the housing (101), receptacle (103), tappet (104) and cradle (108), control their alternating coupling to the traction cable (114) and thus the sequence of the mixing stroke, insertion stroke, injection stroke and return stroke.

2. An injection device according to claim 1, characterized in that first devices are provided for releasably locking the tappet (104) in place in order to initiate the mixing stroke.

3. An injection device according to claim 2, characterized in that the first devices consist of a locking hook (102A) of a spring-actuated first push-button (102) provided on the housing (101), which locking hook (102A) acts on the tappet (104).

4. An injection device according to claim 1, characterized in that second devices are provided for releasably locking the receptacle (103) in place in order to initiate the insertion stroke following the mixing stroke.

5. An injection device according to claim 4, characterized in that the second devices consist of a locking hook (116A) on at least one spring-actuated push-button (116) provided on the housing (101), which locking hook (116A) acts on the receptacle (103).

6. An injection device according to claim 1, characterized in that the traction cable (114) pulls the receptacle (103) with the ampoule and injection needle out of the injection site by means of the cradle (108) and roller (109) during the return stroke following the injection stroke.

7. An injection device according to claim 1, characterized in that third devices are provided for coupling the tappet (104) to the receptacle (103), which couple the tappet (104) to the receptacle (103) in order to carry out the insertion stroke and uncouple it in order to carry out the injection stroke.

8. An injection device according to claim 7, characterized in that the third devices consist of a control lever (109), whose one end is hinged to the tappet (104) and whose other end actuates the receptacle (103).

9. An injection device according to claim 1, characterized in that fourth devices are provided for coupling the cradle (108) and tappet (104), which couple the cradle (108) and tappet (104) from the start of the mixing stroke until the end of the injection stroke.

10. An injection device according to claim 9, characterized in that the fourth devices consist of a spring-actuated driving feature (118), which is mounted in the cradle (108) and which, in its coupled position, acts on the tappet (104).

11. An injection device according to claim 1, characterized in that it incorporates a first adjusting slider (107), which effects a setting of the path of the insertion stroke and, therefore, of the insertion depth.

12. An injection device according to claim 8, characterized in that the first adjusting slider (107) is designed as an end-stop element, which is mounted so as to be displaceable between two end positions as desired, and whose position determines, via the control lever (105), the path of the receptacle (103) and thus the length of the insertion stroke.

13. An injection device according to claim 1, characterized in that it incorporates a second adjusting slider (106), which effects, via the path of the tappet (104), a setting of the length of the injection stroke and thus of the injection amount of the mixed substance.

14. An injection device according to claim 12, characterized in that the second adjusting slider (106) is designed as an end-stop element for the receptacle (103), said end-stop element being mounted so as to be displaceable relative to the first adjusting slider (107) between at least two positions.

15. An injection device according to claim 11, characterized in that one of the adjusting sliders is mounted, slideable or rotatable, directly or indirectly in the respective other adjusting slider, so that the insertion depth and injection volume are adjustable independently from each other.

16. An injection device according to claim 1, characterized in that the housing (101) is composed of two half shells.

17. An injection device according to claim 16, characterized in that at least one of the half shells has a window for monitoring the mixing of the two substances in the front chamber during the mixing stroke.