METHOD AND SYSTEM FOR GENETIC RESEARCH USING GENETIC SAMPLING VIA AN INTERACTIVE ONLINE NETWORK

• US 20080189047A1
• Filed: 11/01/2007
• Published: 08/07/2008
• Est. Priority Date: 11/01/2006
• Status: Abandoned Application

• Current Assignee: 0752004 B.C. Ltd.
• Original Assignee: 0752004 B.C. Ltd.
• Inventors: Ma, Clement K.L., Wong, June T. W.
• Application Number:
  US11/934,024
• Publication Number:
  US 20080189047A1
• Time in Patent Office: Days
• US Class Current: 702/20
• CPC Class Codes: G16B 10/00 ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Abstract

The invention provides a method and system for conducting genetic research using DNA sampling, preferably via an online social network, using a set of family members related by defined genealogical relationships to identify carriers of a DNA of interest for obtaining DNA information. According to various aspects of the invention, the method can be used for identifying and determining carriers of a DNA of interest, and further genealogical analysis.

Claims

1. A computer-implemented method of conducting genetic investigation using a set of individuals related by defined genealogical relationships, comprising:

a) defining a set of living or deceased individuals related by defined genealogical relationships;

b) defining at least one DNA type of interest;

c) defining the inheritance pattern associated with each said at least one DNA type of interest;

d) determining the information associated with each said at least one DNA type of interest;

e) obtaining information in relation to said set of living or deceased individuals, by carrying out an inquiry using the information obtained in at least one of steps a), b), c) or d).

2. The method of claim 1 wherein said inquiry is selected from the group consisting of:

i) selecting a DNA type of interest and determining which information can be obtained by testing said DNA type of interest;

ii) selecting a DNA type of interest and determining which individual in said set carries said DNA type of interest;

iii) selecting a DNA type of interest and determining which ancestral/family line can be traced by testing said DNA type of interest;

iv) selecting an individual from said set and determining which DNA type is carried by said individual;

v) selecting an individual from said set and determining which ancestral/family line can be traced by testing the DNA types carried by said individual;

vi) selecting an individual from said set and determining which ancestral/family line can be traced by testing a DNA type of interest;

vii) selecting an individual from said set and determining which ancestral/family line can be traced by testing each DNA type carried by said individual;

viii) selecting a first individual from said set and determining which additional individuals in said set belong to the same ancestral/family line as said first individual;

ix) selecting a first individual from said set and determining which additional individual in said set carries the same DNA characteristic for said DNA type of interest as said first individual;

x) selecting a first individual from said set and determining which other individuals in said set carry DNA which can provide information for said individual;

xi) selecting a first individual from said set and determining which information for which other individual from said set can be derived from testing said first individual;

xii) selecting a first individual from said set, selecting a second individual from said set and determining which DNA type has the same DNA characteristic for said first individual and said second individual;

xiii) selecting a first individual from said set, selecting a second individual from said set, selecting at least one DNA type and determining whether the DNA characteristic for said at least one DNA type is the same for the said first individual and said second individual;

xiv) selecting an individual from said set, selecting a DNA type and determining whether said individual carries said DNA type;

xv) selecting an individual from said set, selecting a DNA type and determining whether said individual can be tested for said DNA type;

xvi) selecting a first individual from said set, selecting a DNA type and determining which additional individual carries the same DNA characteristic for said DNA type as the said first individual;

xvii) selecting an individual from said set, selecting a DNA type and determining which ancestral/family lineage is traced by testing said individual and said DNA type;

xviii) selecting an individual from said set, selecting ancestral/family line for investigation, determining whether said individual carries the DNA type required to trace said ancestral/family line;

xix) selecting a first individual from said set, selecting an ancestral/family line, determining which additional individual is in the same ancestral/family line as the said first individual;

xx) selecting an ancestral/family line of interest and determining which individual in said set carries the DNA type required to trace said ancestral/family line; and

xxi) selecting an ancestral/family line and determining which individual and which DNA type is required to trace said ancestral/family line.

3. The method of claim 1 wherein said set of living or deceased individuals is a family tree.

4. The method of claim 1 wherein said set of living or deceased individuals is a family list.

5. The method of claim 3 wherein at least one of the following information can be viewed from the family tree:

a) the carriers of genetic information;

b) the DNA characteristics for the DNA type for at least one said individual;

c) the initiation process for genetic analysis.

6. The method of claim 3 wherein the lines to be traced and the test status of said at least one DNA type for the line can be viewed in the family tree.

7. The method of claim 1 wherein a plurality of individuals in the set are linked in an interactive computerized network.

8. The method of claim 7 wherein said interactive computerized network is a social network.

9. The method of claim 8 wherein a plurality of users are accessible to the social network.

10. The method of claim 3 wherein one or more than one of said individuals in said family tree are linked in an interactive computerized network.

11. The method of claim 10 wherein one or more than one of said individuals in said family tree are linked in a social network.

12. The method of claim 1 wherein genetic testing can be initiated for one or more than one individual in the set.

13. The method of claim 12 wherein said genetic testing involves carrying out at least one of the following steps:

a) identifying the individual for genetic testing;

b) identifying the DNA type for genetic testing;

c) identifying the availability of the said individual for genetic testing;

d) identifying the ability to sample DNA from the said individual for genetic testing;

e) identifying the ability to obtain a sample containing the DNA from the said individual for genetic testing;

f) ordering a genetic test for the said individual for at least one DNA type;

g) obtaining a genetic test for an individual in the system.

14. The method of claim 12 wherein the genetic testing can be initiated by notifying another individual to initiate genetic testing.

15. The method of claim 12 wherein one or more than one individual in the set can initiate genetic testing on the individual himself or herself.

16. The method of claim 12 wherein one or more than one individual in the set can initiate genetic testing for one or more than one other individuals in the set.

17. The method of claim 10 wherein the initiation of genetic testing is facilitated by the computerized network.

18. The method of claim 12 wherein said genetic testing can be conducted on the DNA of said individual to determine the DNA characteristic of said one or more than one DNA type.

19. The method of claim 12 wherein the initiation of genetic testing can be by means of ordering a genetic test or asking another individual to order a genetic test.

20. The method of claim 12 wherein an individual can access the DNA information for himself or herself.

21. The method of claim 12 wherein one or more than one individual can access the DNA information for one or more than one additional other individual in the set.

22. The method of claim 12 wherein one or more than one individual in the set can use the system to determine who can be tested, and then either ask the individual to test or facilitate the testing for the individual.

23. The method of claim 1 wherein family lines can be defined by the type of genealogical relationships between individuals in the set.

24. The method of claim 3 wherein the carriers of genetic information can be viewed in the family tree.

25. The method of claim 3 wherein a family line to be traced can be viewed in the family tree.

26. The method of claim 1 further comprising the step of sampling the DNA of least one carrier of said DNA type of interest in said set.

27. The method of claim 26 further comprising the step of determining what information the testing of an individual in the set will contribute prior to sampling the DNA of at least one said carrier.

28. The method of claim 27 further comprising the step of determining whether said carrier is living or deceased, and if said carrier is deceased then determining if said deceased carrier'"'"'s genetic information is known, and if not, then determining whether a forensic DNA sample can be obtained and, if so, obtaining said forensic DNA sample for analysis.

29. The method of claim 1 wherein said DNA type of interest is Y-DNA and a male is specified as the carrier of Y-DNA.

30. The method of claim 29 wherein the paternal line of a first individual in said set is traced by determining whether said first individual carries Y-DNA and whether said first individual can be tested.

31. The method of claim 30 comprising the further step of determining whether any other individuals in said set carries Y-DNA with the same characteristics as the Y-DNA of said first individual and whether said other individuals can be tested.

32. The method of claim 1 wherein said DNA type of interest is mtDNA and a male or female is specified as the carrier of mtDNA.

33. The method of claim 32 wherein the maternal line of a first individual in said set is traced by determining whether said first individual carries mtDNA and whether said first individual can be tested.

34. The method of claim 33 comprising the further step of determining whether any other individuals in said set carries mtDNA with the same characteristics as the mtDNA of said first individual and whether said other individuals can be tested.

35. The method of claim 1 comprising adding further individuals to the set until one or more than one individual who carries the DNA type of interest is identified.

36. The method of claim 35 wherein additional individuals are added to the set of individuals related by defined genealogical relationships until at least one individual who carries a DNA marker required to trace the ancestral/family line of interest is added.

37. The method of claim 1 further comprising the step of determining whether it is possible to sample the DNA from at least one of said individuals for DNA testing.

38. The method of claim 37 wherein when the DNA of said at least one of said individuals cannot be sampled for DNA testing, additional individuals in said set which carry the same DNA type as the said first individual are determined and the possibility of sampling the DNA of said additional individuals is determined.

39. The method of claim 37 wherein when the DNA of said individual cannot be sampled, a forensic specimen containing the DNA of said individual is tested.

40. The method of claim 38 wherein when the DNA of said additional individual cannot be sampled, a forensic specimen containing the DNA of said individual is tested.

41. The method of claim 26 further comprising the step of determining whether said carrier is living or deceased, and if said carrier or additional carrier is deceased, then determining if said deceased carrier'"'"'s genetic information is known, and if not, then determining whether a forensic DNA sample can be obtained, and if so, obtaining said forensic DNA sample for analysis.

42. The method of claim 1 wherein said inquiry comprises determining the possibility of tracing an ancestral/family line of interest and determining the individual who carries the DNA type required to trace said ancestral/family line of interest.

43. The method of claim 42 wherein when no individual in the set carries the DNA type required to trace the ancestral/family line, individuals are added to the set and the inquiry in claim 40 is repeated until at least one individual who carries the DNA type required to trace the ancestral/family line of interest is identified.

44. The method of claim 42 wherein additional individuals are added to the set of individuals related by defined genealogical relationships until an individual who carries the DNA marker required to trace the ancestral/family line of interest is added.

45. A computer-implemented system for conducting genetic investigation using a set of individuals related by defined genealogical relationships, comprising:

a) computer-implemented means for defining and storing a set of living or deceased individuals related by defined genealogical relationships;

b) computer-implemented means for defining at least one DNA type of interest;

c) computer-implemented means for defining the inheritance pattern associated with each said at least one DNA type of interest;

d) computer-implemented means for defining the information associated with each said at least one DNA type of interest;

e) computer-implemented means for obtaining genetic information in relation to said set of living or deceased individuals, by carrying out a chain of inquiry using said at least one DNA type of interest, and said inheritance pattern associated with each said at least one DNA type of interest.