OPHTHALMIC COMPOSITIONS CONTAINING A SYNERGISTIC COMBINATION OF THREE POLYMERS
First Claim
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1. An aqueous composition suitable for ophthalmic administration comprising three polymeric ingredients having a synergistic effect on the composition'"'"'s viscosity wherein the three polymeric ingredients are a) hyaluronic acid, b) guar gum, and c) hydroxypropyl methylcellulose or a carboxyvinyl polymer, provided that if the composition comprises a carboxyvinyl polymer then the composition does not contain sodium chloride or boric acid.
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Abstract
Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity.
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Citations
21 Claims
- 1. An aqueous composition suitable for ophthalmic administration comprising three polymeric ingredients having a synergistic effect on the composition'"'"'s viscosity wherein the three polymeric ingredients are a) hyaluronic acid, b) guar gum, and c) hydroxypropyl methylcellulose or a carboxyvinyl polymer, provided that if the composition comprises a carboxyvinyl polymer then the composition does not contain sodium chloride or boric acid.
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9. The composition of claim 9 wherein the ophthalmic drug is selected from the group consisting of anti-glaucoma agents;
- anti-angiogenesis agents;
anti-infective agents;
non-steroidal and steroidal anti-inflammatory agents;
growth factors;
immunosuppressant agents; and
anti-allergic agents.
- anti-angiogenesis agents;
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10. An aqueous composition for use as an artificial tear wherein the composition consists essentially of a) hyaluronic acid;
- b) hydroxypropyl guar;
c) hydroxypropyl methylcellulose or a carboxyvinyl polymer; and
d) mannitol, wherein the composition has a pH of 6-8 and an osmolality in the range of 220-340 mOsm/kg.
- b) hydroxypropyl guar;
- 11. A method of alleviating the symptoms of dry eye comprising topically administering to the eye a composition comprising three polymeric ingredients having a synergistic effect on the composition'"'"'s viscosity wherein the three polymeric ingredients are a) hyaluronic acid, b) guar gum, and c) hydroxypropyl methyl cellulose or a carboxyvinyl polymer, provided that if the composition comprises a carboxyvinyl polymer then the composition does not contain sodium chloride or boric acid.
- 17. A method of treating a disease or condition of the eye comprising administering to the eye a composition comprising an ophthalmic drug and a carrier wherein the carrier comprises three polymeric ingredients having a synergistic effect on the composition'"'"'s viscosity and wherein the three polymeric ingredients are a) hyaluronic acid, b) guar gum, and c) hydroxypropyl methyl cellulose or a carboxyvinyl polymer, provided that if the composition comprises a carboxyvinyl polymer then the composition does not contain sodium chloride or boric acid.
Specification