Use of a Gsk-3 Inhibitor to Maintain Potency of Culture Cells
First Claim
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1. A culture method comprising culturing non-embryonic cells in the presence of at least one GSK-3 inhibitor, wherein said cells can differentiate into cell types of more than one embryonic lineage.
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Abstract
The present invention is directed to the culture of non-embryonic cells, that can differentiate into cell types of more than one embryonic lineage, in culture under conditions that maintain differentiation capacity during expansion; more particularly, culturing non-embryonic cells in the presence of at least one GKS-3 inhibitor, such as BIO.
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Citations
48 Claims
- 1. A culture method comprising culturing non-embryonic cells in the presence of at least one GSK-3 inhibitor, wherein said cells can differentiate into cell types of more than one embryonic lineage.
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2-29. -29. (canceled)
- 42. A composition comprising non-embryonic cells in combination with at least one GSK-3 inhibitor, wherein said cells can differentiate into cell types of more than one embryonic lineage.
- 45. A method to prepare a composition comprising admixing non-embryonic cells and at least one GSK-3 inhibitor, wherein said cells can differentiate into cell types of more than one embryonic lineage.
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