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ENRICHMENT AND SEQUENCE ANALYSIS OF GENOMIC REGIONS

  • US 20080194414A1
  • Filed: 01/08/2008
  • Published: 08/14/2008
  • Est. Priority Date: 04/24/2006
  • Status: Abandoned Application
First Claim
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1. A method of reducing the genetic complexity of a population of nucleic acid molecules, the method comprising the steps of:

  • (a) providing on a solid support single-stranded nucleic acid molecules of said population captured by specific hybridization to multiple, different oligonucleotide probes, wherein said nucleic acid molecules have an average size selected from the group consisting of about 100 to about 1000 nucleotide residues, about 250 to about 800 nucleotide residues and about 400 to about 600 nucleotide residues,(b) separating unbound and non-specifically hybridized nucleic acids from the captured molecules;

    (c) eluting the captured molecules from the solid support, and(d) optionally repeating steps (a) to (c) for at least one further cycle with the eluted captured molecules.

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