Medicament For the Treatment of Central Nervous System Disorders

• US 20080194631A1
• Filed: 07/26/2005
• Published: 08/14/2008
• Est. Priority Date: 07/26/2004
• Status: Abandoned Application

• Current Assignee: Greenpharma SAS, Key Obs
• Original Assignee: Greenpharma SAS, Key Obs
• Inventors: Bernard, Philippe, Trovero, Fabrice
• Application Number:
  US11/658,643
• Publication Number:
  US 20080194631A1
• Time in Patent Office: Days
• US Class Current: 514/325
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/451 having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 25/32 Alcohol-abuse
• CPC Class Codes: A61P 25/34 Tobacco-abuse
• CPC Class Codes: A61P 25/36 Opioid-abuse

Abstract

The invention relates to the use of a molecule, alone or in combination, chosen from the group of molecules having a simultaneous antagonist action on the alpha1-noradrenergic, glutamatergic NMDA and serotoninergic 5HT2 receptors, for the preparation of a medicament intended for treating pathologies of the central nervous system.

Claims

1. The use of a molecule, alone or in combination, chosen from the group of molecules having a simultaneous antagonist action on the alpha1-noradrenergic, glutamatergic NMDA and serotoninergic 5HT2 receptors, for the preparation of a medicament intended for treating pathologies of the central nervous system.

2. The use as claimed in claim 1, wherein the pathologies are chosen from pharmacodependences, psychosis, nicotine addiction, disorders linked to alcohol consumption, schizophrenia, acute and chronic psychotic states, dementia, mood disorders, attention disorders, sleep disorders, impulsivity disorders, hyperactivity, states of dependence on addictive substances, dependence on alcohol, dependence on psychostimulants, dependence on opiates, dependence on benzodiazepines, dependence on tobacco, dependence on gambling.

3. The use as claimed in claim 1, wherein the group of molecules having a simultaneous antagonist action on the alpha1-noradrenergic, glutamatergic NMDA and serotoninergic 5HT2 receptors consists of the following molecules:

1-(1-naphthyl)piperazine, seganserin, olanzapine, sarprogelate, mirtazapine, aripiprazole, mepiprazole, 4-(4-fluorobenzoyl)-1-(4-phenylbutyl)piperidine, AMI-193, amperozide, cinanserin, clozapine, cyclobenzaprine, ketanserin, MDL 11,939, metergoline, methiothepin, methysergide, mianserin, N-desmethylclozapine, piperazine, pirenperone, ritanserin, RS 102221, sertindole, SB 200646, SB 204741, SDZ SER 082, spiperone, AH 11110, amosulalol, corynanthine, HEAT, naftopidil, niguldipine, bunazosin, dapiprazole, prazosin, tamsulosin, RS 100329, RS 17053, terazosin, WB 4101, urapidil, 5-methylurapidil, (−

)-MK801, (+)-MK801, (+/−

)-1-(1,2-diphenylethyl)piperidine, (2R, 3S)-Chlorpheg, (R)-4-carboxyphenyglycine, (R)-CPP, (RS)-CPP, arcaine, CGP 37849, CGP 39551, CGS 19755, D-AP5, D-AP7, DL-APS, DL-AP7, L-AP5, loperamide, LY 235959, memantine, SDZ 220-040, SDZ 220-581, synthalin, and their pharmacologically acceptable salts.

4. The use as claimed in claim 1, wherein at least one of the molecules is Ifenprodil.

5. The use as claimed in claim 1, wherein at least one of the molecules is cyproheptadine.

6. The use as claimed in claim 1, wherein the molecules are administered at a daily dose of between 0.1 mg and 1000 mg per day.

7. A pharmaceutical composition comprising at least two molecules chosen from the group of molecules having a simultaneous antagonist action on the alpha1-noradrenergic, glutamatergic NMDA and serotoninergic 5HT2 receptors consisting of the following molecules:

1-(1-naphthyl)piperazine, seganserin, olanzapine, sarprogelate, mirtazapine, aripiprazole, mepiprazole, 4-(4-fluorobenzoyl)-1-(4-phenylbutyl)piperidine, AMI-193, amperozide, cinanserin, clozapine, cyclobenzaprine, ketanserin, MDL 11,939, metergoline, methiothepin, methysergide, mianserin, N-desmethylclozapine, piperazine, pirenperone, ritanserin, RS 102221, sertindole, SB 200646, SB 204741, SDZ SER 082, spiperone, AH 11110, amosulalol, corynanthine, HEAT, naftopidil, niguldipine, bunazosin, dapiprazole, prazosin, tamsulosin, RS 100329, RS 17053, terazosin, WB 4101, urapidil, 5-methylurapidil, (−

)-MK801, (+)-MK801, (+/−

)-1-(1,2-diphenylethyl)piperidine, (2R, 3S)-Chlorpheg, (R)-4-carboxyphenyglycine, (R)-CPP, (RS)-CPP, arcaine, CGP 37849, CGP 39551, CGS 19755, D-AP5, D-AP7, DL-APS, DL-AP7, L-AP5, loperamide, LY 235959, memantine, SDZ 220-040, SDZ 220-581, synthalin, and their pharmacologically acceptable salts, combined with a pharmaceutically acceptable vehicle or excipient.

8. The pharmaceutical composition as claimed in claim 7, wherein the content of molecule in the composition is between 0.1 mg and 1000 mg.

9. The pharmaceutical composition as claimed in claim 7, wherein the combined molecules are Ifenprodil and cyproheptadine.

10. The pharmaceutical composition as claimed in claim 9, wherein the content of molecule in the composition is between 0.1 mg and 1000 mg.