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Photoacoustic Assay Method and Apparatus

  • US 20080194929A1
  • Filed: 03/29/2004
  • Published: 08/14/2008
  • Est. Priority Date: 04/01/2003
  • Status: Abandoned Application
First Claim
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1. Apparatus for assaying a target analyte in a localized tissue region that may include the target and other analytes comprising:

  • a light source that illuminates the region with light at each of a plurality of wavelengths at which light is absorbed and/or scattered by tissue in the region wherein light at at least one of the wavelengths is absorbed or and/or scattered by the target analyte;

    a signal generator that generates signals responsive to intensity of the light from the light source at different locations in the localized region; and

    a controller that;

    receives the generated signals;

    processes the signals to determine an extinction coefficient for light in the localized region at each wavelength; and

    determines the concentration of the target analyte responsive to a solution of a set of simultaneous equations having as unknown variables concentrations of a plurality of analytes in the region, one of which is the target analyte, wherein each equation in the set expresses a relationship between the extinction coefficient, the absorption coefficient and/or the reduced scattering coefficient for light at a different one of the plurality of wavelengths and at least one of the equations expresses a relationship between the extinction coefficient and the reduced scattering coefficient.

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