Applicators for Multiple Component Formulations and the Like, and Methods of Use Thereof

• US 20080195040A1
• Filed: 01/25/2008
• Published: 08/14/2008
• Est. Priority Date: 01/25/2007
• Status: Active Grant

• Current Assignee: SQUARE 1 BANK
• Original Assignee: HyperBranch Medical Technology, Inc. (Stryker Corporation)
• Inventors: D'Alessio, Keith R., Clark, Jeffrey A.
• Granted Patent: US 8,262,608 B2
• Time in Patent Office: Days
• US Class Current: 604/87
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61B 2017/320012 Brushes
• CPC Class Codes: A61B 2090/037 with a frangible part, e.g. by reduced diameter
• CPC Class Codes: A61J 1/065 Rigid ampoules, e.g. glass ampoules
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61M 35/006 using sponges, foams, absorbent pads or swabs as spreading means

Abstract

One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.

Claims

1. An applicator, comprising an applicator body, a tip and a cap;

wherein the applicator body comprises a storage receptacle for a liquid portion, a closed proximal end, an open distal end, and a friable seal or a removable separator separating the storage receptacle for the liquid portion from the open distal end;

the tip comprises an open proximal end connected to the open distal end of the applicator body, and an open distal end;

the cap covers the open distal end of the tip in a non-airtight manner; and

the tip or the cap comprises a storage receptacle for a solid portion.

2. The applicator of claim 1, wherein the applicator body further comprises a liquid in the storage receptacle for a liquid portion;

and the liquid comprises a polyalkyleneimine.

3. The applicator of claim 1, wherein the tip is a flow-thru brush.

4. The applicator of claim 1, wherein only the tip comprises a storage receptacle for a solid portion.

6. The applicator of claim 1, wherein only the cap comprises a storage receptacle for a solid portion.

8. The applicator of claim 1, wherein the applicator body comprises a friable seal.

5. The applicator of claim 5, wherein the tip further comprises a solid in the storage receptacle for a solid portion;

and the solid is an activated PEG.

7. The applicator of claim 7, wherein the cap further comprises a solid in the storage receptacle for a solid portion;

and the solid is an activated PEG.

9. An applicator, comprising an applicator body and a tip;

wherein the applicator body comprises a first storage receptacle for a first liquid portion, a second storage receptacle for a second liquid portion, a closed proximal end, and an open distal end; and

the tip comprises an open distal end, and an open proximal end connected to the open distal end of the applicator body.

10. The applicator of claim 9, further comprising a screen or filter placed between the open distal end of the applicator body and the open proximal end of the tip.

11. The applicator of claim 9, wherein the first storage receptacle is a crushable ampoule;

and the second storage receptacle is a crushable ampoule.

12. The applicator of claim 9, wherein the applicator body further comprises a solid;

and the solid is an activated PEG.

13. The applicator of claim 9, the present invention relates to the aforementioned applicator, wherein the tip is a flow-thru brush.

14. The applicator of claim 9, wherein the applicator body further comprises a first liquid portion in the first storage receptacle;

and the first liquid portion comprises a polyalkyleneimine, epoxy-resin component or polyurethane prepolymer.

15. The applicator of claim 9, wherein the applicator body further comprises a second liquid portion in the second storage receptacle;

and the second liquid portion comprises a buffer or curing agent.

16. The applicator of claim 9, wherein the applicator body is divided by friable seals into a proximal compartment, a middle compartment, and a distal compartment;

the proximal compartment and the middle compartment are separated by a first friable seal;

the middle compartment and the distal compartment are separated by a second friable seal;

the proximal compartment is the first storage receptacle; and

the middle compartment is the second storage receptacle.

17. The applicator of claim 13, wherein the distal compartment comprises a solid in a crushable ampoule;

and the solid comprises an activated PEG.

18. The applicator of claim 13, wherein the first friable seal comprises wax;

and the second friable seal comprises wax.

19. An applicator, comprising an applicator body, a tip and a bladder;

wherein the applicator body comprises a storage receptacle for a liquid portion, a closed proximal end, an open distal end, and a friable seal or a removable separator separating the storage receptacle for the liquid portion from the open distal end;

the tip comprises an open proximal end connected to the open distal end of the bladder, and an open distal end;

the bladder comprises an open distal end that connects to the tip, and an open proximal end that connects to the applicator body.

20. The applicator of claim 19, wherein the applicator body further comprises a liquid in the storage receptacle for a liquid portion;

and the liquid portion comprises a polyalkyleneimine.

21. The applicator of claim 19, wherein the tip is a flow-thru brush.

22. The applicator of claim 19, wherein the bladder comprises a storage receptacle for a solid portion;

the bladder further comprises a solid in the storage receptacle for a solid; and

the solid is an activated PEG.

23. The applicator of claim 19, wherein the applicator body comprises a friable seal at the distal end of the applicator body.

24. The applicator of claim 23, wherein the first friable seal comprises wax;

and the second friable seal comprises wax.

25. The applicator of claim 19, further comprising a cap which engages the proximal end of the tip;

and further comprises a solid receptacle.

26. A hand-held brush applicator, comprising a handle, a brush and a solid;

wherein the brush is connected to one end of the handle; and

the solid is adsorbed onto the brush.

27. The hand-held brush applicator of claim 26, wherein the solid is an activated PEG.

28. A composition comprising a solid and a activate PEG, wherein the activated PEG is adsorbed onto the solid.

29. The solid of claim 28, wherein the solid is porous plastic.