SAMPLING OF BLOOD ANALYTES
First Claim
Patent Images
1. A device for insertion into a subject, the device comprising:
- (a) a housing suitable for disposition in a subject'"'"'s body fluid;
(b) a probe comprising a support coupled to the housing; and
(c) a binding agent located on or in the support.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides for devices and methods of sampling and analyzing body fluid analytes, including proteins, nucleic acids, drugs, carbohydrates and lipids. Body fluids include blood, serum, sputum, saliva, urine, cerebrospinal fluid, and ascites.
18 Citations
88 Claims
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1. A device for insertion into a subject, the device comprising:
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(a) a housing suitable for disposition in a subject'"'"'s body fluid; (b) a probe comprising a support coupled to the housing; and (c) a binding agent located on or in the support. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 22, 23, 24, 25, 26, 27, 61)
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15-21. -21. (canceled)
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28. A method of recovering an analyte comprising:
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(i) providing a device for insertion into a fluid located in a subject, the device comprising; (a) a housing; (b) a probe comprising a support coupled to the housing; and (c) a binding agent located on or in the support, (ii) inserting the device into the fluid of the subject such that the support is brought into contact with the subject'"'"'s fluid; and (iii) removing the device and/or support from the subject. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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29-36. -36. (canceled)
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51. A method of assaying for a body fluid analyte comprising:
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(i) providing a device for insertion into a subject'"'"'s body fluid, the device comprising; (a) a housing suitable for disposition in a subject'"'"'s body fluid; (b) a probe comprising a support coupled to the housing; and (c) a binding agent coupled to the probe with at least a support, (ii) inserting the device into the body fluid of the subject such that the support is brought into contact with the subject'"'"'s body fluid; (iii) removing the device and/or support from the subject; (iv) analyzing the support for the presence, amount and/or state of the analyte. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 62)
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63. A device suitable for insertion into a subject'"'"'s body fluid, the device comprising:
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(a) a probe comprising a support coupled to the housing; and (b) a binding agent located on or in the support.
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64-68. -68. (canceled)
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69. A device suitable for insertion into a subject'"'"'s body fluid, the device comprising:
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(a) a housing having a portion sized for placement in a subject'"'"'s blood vessel; (b) a probe comprising a support coupled to the housing; and (c) a binding agent located on or in the support.
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70-77. -77. (canceled)
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78. A device suitable for insertion into a subject'"'"'s body fluid, the device comprising:
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(a) a housing having a portion sized for placement in a subject'"'"'s blood vessel; (b) a probe having a distal portion sized for insertion through the housing; and (c) a binding agent coupled to the probe with at least a support.
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79-86. -86. (canceled)
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87. A device suitable for insertion into a subject'"'"'s body fluid, the device comprising:
- a probe; and
a binding agent coupled to the probe with at least a support;
the binding agent exhibiting affinity for one or more components found in said body fluid.
- a probe; and
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88-93. -93. (canceled)
Specification