SYSTEM AND METHOD FOR TREATING PARKINSON'S DISEASE AND OTHER MOVEMENT DISORDERS

• US 20080195175A1
• Filed: 10/04/2007
• Published: 08/14/2008
• Est. Priority Date: 03/08/2001
• Status: Active Grant

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Northstar Neuroscience, Inc.
• Inventors: Wyler, Allen, Balzer, Jeffrey
• Granted Patent: US 7,962,218 B2
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Systems and methods for treating movement disorders using cortical stimulation. In one embodiment, a method for treating movement disorders comprises determining a site at the cortex of the brain of a patient related to a movement disorder of an afflicted body part. The site can be determined by obtaining a representation of neural activity occurring in the cortex of the patient and correlating an area of neural activity with the afflicted body part. The method can also include applying neural stimulation, such as electrical or magnetic waveforms, directly to the site.

Claims

1. A method for treating movement disorders, comprising:

providing an image showing a relative position between an external marker on a patient and at least one of the central sulcus, the precentral gyrus and/or the postcentral gyrus of the patient;

identifying a stimulation site proximate to the dura of the patient and over the precentral gyrus relative to the external marker; and

applying neural stimulation directly to the stimulation site.

2. The method of claim 1, further comprising implanting an electrode at the stimulation site, and wherein applying neural stimulation comprises passing an electrical current through the electrode.

3. The method of claim 2 wherein implanting the electrode comprises positioning an array having a plurality of electrodes over only the precentral gyrus of the patient.

4. The method of claim 2 wherein implanting the electrode comprises positioning an array having a plurality of electrodes such that at least one electrode is over the precentral gyrus and at least one other electrode is over the postcentral gyrus of the patient.

5. The method of claim 1, further comprising implanting an electrode array having a plurality of first electrodes arranged in a first row and a plurality of second electrodes arranged in a second row at the stimulation site, and wherein applying neural stimulation comprises passing an electrical current through at least one of the electrodes.

6. The method of claim 5 wherein implanting the electrode array comprises positioning the first and second rows at an oblique angle relative to the central sulcus.

7. The method of claim 5 wherein implanting the electrode array comprises positioning one of the first electrodes and one of the second electrodes over the precentral gyrus of the patient, and positioning another one of the first electrodes and another one of the second electrodes over the postcentral gyrus of the patient.

8. The method of claim 1 wherein applying neural stimulation directly to the stimulation site comprises delivering an electrical current directly to the dura of the patient at the stimulation site.

9. The method of claim 1 wherein applying neural stimulation directly to the stimulation site comprises delivering an electrical current directly to the patient at least proximate to the dura over the stimulation site.

10. The method of claim 9 wherein delivering an electrical current directly to the patient comprises applying a unipolar electrical potential to an electrode implanted at the stimulation site.

11. The method of claim 9 wherein delivering an electrical current directly to the patient comprises applying a unipolar electrical potential to a plurality of electrodes implanted at the stimulation site.

12. The method of claim 9 wherein delivering an electrical current directly to the patient comprises applying a bipolar electrical potential to a plurality of electrodes implanted at the stimulation site.

13. The method of claim 1 wherein the patient has a movement disorder that is worse on a first side of the patient than on a second side of the patient opposite the first side, and wherein the method further comprises implanting an electrode over the precentral gyrus on the second side of the patient only.

14. A method for treating movement disorders, comprising:

locating a stimulation site at least proximate to the dura and along the precentral gyrus of a patient by imaging at least one of the precentral gyrus, central sulcus and/or postcentral gyrus of the patient relative to an external marker on the patient; and

applying neural stimulation directly to the stimulation site.

15. The method of claim 14, further comprising implanting an electrode at the stimulation site, and wherein applying neural stimulation comprises passing an electrical current through the electrode.

16. The method of claim 15 wherein implanting the electrode comprises positioning an array having a plurality of electrodes over only the precentral gyrus of the patient.

17. The method of claim 15 wherein implanting the electrode comprises positioning an array having a plurality of electrodes such that at least one electrode is over the precentral gyrus and at least one other electrode is over the postcentral gyrus of the patient.

18. The method of claim 14, further comprising implanting an electrode array having a plurality of first electrodes arranged in a first row and a plurality of second electrodes arranged in a second row at the stimulation site, and wherein applying neural stimulation comprises passing an electrical current through at least one of the electrodes.

19. The method of claim 18 wherein implanting the electrode array comprises positioning the first and second rows at an oblique angle relative to the central sulcus.

20. The method of claim 18 wherein implanting the electrode array comprises positioning one of the first electrodes and one of the second electrodes over the precentral gyrus of the patient, and positioning another one of the first electrodes and another one of the second electrodes over the postcentral gyrus of the patient.

21. The method of claim 14 wherein applying neural stimulation directly to the stimulation site comprises delivering an electrical current directly to the dura of the patient at the stimulation site.

22. The method of claim 14 wherein applying neural stimulation directly to the stimulation site comprises delivering an electrical current directly to the patient at least proximate to the dura over the stimulation site.

23. The method of claim 22 wherein delivering an electrical current directly to the patient comprises applying a unipolar electrical potential to an electrode implanted at the stimulation site.

24. The method of claim 22 wherein delivering an electrical current directly to the patient comprises applying a unipolar electrical potential to a plurality of electrodes implanted at the stimulation site.

25. The method of claim 22 wherein delivering an electrical current directly to the patient comprises applying a bipolar electrical potential to a plurality of electrodes implanted at the stimulation site.

26. The method of claim 14 wherein the patient has a movement disorder that is worse on a first side of the patient than on a second side of the patient opposite the first side, and wherein the method further comprises implanting an electrode over the precentral gyrus on the second side of the patient only.

27-46. -46. (canceled)

47. A method for treating movement disorders, comprising:

determining a site at the cortex of the brain of a patient related to a movement disorder of an afflicted body part by obtaining a representation of neural activity occurring in the cortex of the patient and correlating an area of neural activity with the afflicted body part; and

applying neural stimulation directly to the site.

48. The method of claim 47, further comprising implanting an electrode proximate to the dura mater at the site, and wherein applying neural stimulation to the site comprises electrically biasing the electrode.

49. The method of claim 47 wherein obtaining a representation of neural activity occurring in the cortex comprises imaging neural activity in the cortex using a neural imaging technique while the patient mentally concentrates on moving the afflicted body part.

50. The method of claim 47 wherein obtaining a representation of neural activity occurring in the cortex comprises imaging neural activity in the cortex using a neural imaging technique while the patient moves the afflicted body part.

51. The method of claim 47 wherein obtaining a representation of neural activity occurring in the cortex comprises imaging neural activity in the cortex using a neural imaging technique while applying an electrical pulse to the afflicted body part.

52. The method of claim 47 wherein obtaining a representation of neural activity occurring in the cortex comprises imaging neural activity in the cortex using a neural imaging technique while an entity other than the patient passively moves the afflicted body part.

53. The method of claim 47 further comprising implanting an electrode proximate to the dura mater at the site, and wherein applying neural stimulation to the site comprises applying an electrical waveform having a frequency of approximately 50-500 Hz.

54. The method of claim 47 further comprising implanting an electrode proximate to the dura mater at the site, and wherein applying neural stimulation to the site comprises applying an electrical waveform having a frequency of approximately 90-130 Hz.

55. The method of claim 47 further comprising implanting an electrode proximate to the dura mater at the site, and wherein applying neural stimulation to the site comprises applying an electrical waveform having a frequency of approximately 100 Hz.

56. The method of claim 47 further comprising implanting an electrode proximate to the dura mater at the site, and wherein applying neural stimulation to the site comprises applying an electrical waveform having a frequency of approximately 120 Hz.

57. A method of treating movement disorders, comprising:

providing a representation of neural activity in the cortex of the brain of a patient;

identifying an area of neural activation on the representation expected to be related to a body part of the patient affected by a movement disorder;

selecting a stimulation site on the patient by referencing the identified area of neural activation to the anatomy of the brain of the patient; and

applying electrical stimulation to the cortex of the patient at the stimulation site.

58. The method of claim 57 wherein providing a representation of neural activity and identifying an area of neural activity related to the affected body part comprises imaging neural activity in the cortex using a neural imaging technique while the patient mentally concentrates on moving the affected body part and noting an area on the image reacting to the mental concentration of the patient.

59. The method of claim 57 wherein providing a representation of neural activity and identifying an area of neural activity related to the affected body part comprises imaging neural activity in the cortex using a neural imaging technique while the patient moves the affected body part and noting an area on the image reacting to the movement of the affected body part.

60. The method of claim 57 wherein providing a representation of neural activity and identifying an area of neural activity related to the affected body part comprises imaging neural activity in the cortex using a neural imaging technique while applying an electrical pulse to the affected body part and noting an area on the image reacting to the electrical pulse applied to the affected body part.

61. The method of claim 57 wherein providing a representation of neural activity and identifying an area of neural activity related to the affected body part comprises imaging neural activity in the cortex using a neural imaging technique while an entity other than the patient passively moves the affected body part and noting an area on the image reacting to movement of the affected body part.

62-65. -65. (canceled)