DEGRADABLE POROUS IMPLANT STRUCTURE
First Claim
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1. A stent including at least one section composed of a material having a particular structure, the stent comprising:
- a plurality of material particles composed at least partially of a biodegradable material and which are arranged in a matrix structure that embed a plurality of pores so as to form an open porous structure, wherein at least one of the material particles are joined at at least one first contact surface thereof to an adjacent one of the material particles at least one second contact surface thereof, and wherein an average size of the pores is larger than an average size of the material particles.
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Abstract
Exemplary embodiments of the present invention relate to a stent, and in particular to at least partially biodegradable stent having at least one section made of a material having a particular porous structure.
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Citations
35 Claims
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1. A stent including at least one section composed of a material having a particular structure, the stent comprising:
a plurality of material particles composed at least partially of a biodegradable material and which are arranged in a matrix structure that embed a plurality of pores so as to form an open porous structure, wherein at least one of the material particles are joined at at least one first contact surface thereof to an adjacent one of the material particles at least one second contact surface thereof, and wherein an average size of the pores is larger than an average size of the material particles.
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2. The stent of claim 1, wherein the section is a supporting structure of the stent.
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3. The stent of claim 1, wherein the section determines at least one part of a form of the stent.
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4. The stent of claim 1, wherein the section has a form of at least one of a ring, a torus, a hollow cylinder segment, a tube segment, or a web structure.
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5. The stent of of claim 1, wherein a pore-particle-ratio of the average size of the pores and the average size of the material particles is larger then two.
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6. The stent of claim 1, wherein the at least one and the adjacent one of the material particles are joined at the respective first and second contact surfaces in a sintering process.
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7. The stent of claim 1, wherein the particular structure has a porosity in the range of about 10 to 90%
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8. The stent of claim 1, wherein the particular structure has a porosity in the range of about 30 to 90%
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9. The stent of claim 1, wherein the particular structure has a porosity in the range of about 50 to 90.
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10. The stent of claim 1, wherein the particular structure has a porosity in the range of about 60%
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11. The stent of claim 1, wherein a ratio of the material particles and the pores is designed to obtain a specific structure weight of a structure of the pores in a range from about 0.1 up to 100 g/cubic centimeter.
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12. The stent of claim 1, wherein a ratio of the material particles and the pores is designed to obtain a specific structure weight of a structure of the pores in a range from about 0.3 up to 5.0 g/cubic centimeter.
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13. The stent of claim 1, wherein a ratio of the material particles and the pores is designed to obtain a specific structure weight of a structure of the pores in a range from about 0.8 to 3.0 g/cubic centimeter.
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14. The stent of claim 1, wherein a shape and the matrix structure of the material particles is designed to obtain a specific matrix weight of the matrix structure in the range of about 0.5 up to 1.9 g/cubic centimeter
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15. The stent of claim 1, wherein a shape and the matrix structure of the material particles is designed to obtain a specific matrix weight of the matrix structure in the range of about 1.0 to 4.0 g/cubic centimeter.
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16. The stent of claim 1, wherein a shape and the matrix structure of the material particles is designed to obtain a specific matrix weight of the matrix structure in the range of about 1.2 to 2.5 g/cubic centimeter.
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17. The stent of claim 1, wherein the particular material includes at least one biodegradable inorganic material selected from at least one of a metal or alloy, a ceramic, a composite, or an organic material selected from polymeric materials.
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18. The stent of claim 1, wherein a particle size of the material particles is in a range of about 500 μ
- m to about 500 μ
m.
- m to about 500 μ
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19. The stent of claim 1, wherein a pore size of the pores is in a range of about 5 nm to 5000 μ
- m.
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20. The stent of claim 1, wherein a pore size of the pores is in a range of about 10 nm to 1000 μ
- m.
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21. The stent of claim 1, wherein a pore size of the pores is in a range of about 20 nm to 700 μ
- m.
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22. The stent of claim 1, wherein an interior of the pores is coated with a coating.
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23. The stent of claims 5, wherein the pore-particle-ratio is larger than about 5.
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24. The stent of claim 23, wherein the pore-particle-ratio is larger than about 20.
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25. The stent of claim 14, wherein the shape of the material particles includes at least one of spheres, cubes, fibers or dendrites.
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26. The stent of claim 1, wherein the pores in a first hierarchy substantially cover a convex polyhedron.
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27. The stent of claim 1, wherein at least a part of the pores in a further hierarchy substantially cover a combination of a convex polyhedron and at least one partial convex sub-polyhedron, wherein a size of the polyhedron is larger than or equal to a size of the sub-polyhedron.
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28. The stent of claim 27, wherein a ratio between the size of the polyhedron and the at least one sub-polyhedron is in the range of about 1:
- 0.5 to 1;
0.001.
- 0.5 to 1;
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29. The stent of claim 27, wherein a ratio between the size of the polyhedron and the at least one sub-polyhedron is in the range of about 1:
- 0.4 to 1;
0.01.
- 0.4 to 1;
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30. The stent of claim 27, wherein a ratio between the size of the polyhedron and the at least one sub-polyhedron is in the range of about 1:
- 0.2.
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31. The stent of claim 1, further comprising at least one active ingredient.
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32. The stent of claim 31, wherein the at least one active ingredient is configured to be released in-vivo.
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33. The stent of claim 31, wherein the at least one active ingredient includes at least one of a pharmacologically, therapeutically, biologically or diagnostically active agent or an absorptive agent.
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34. The stent of claim 1, wherein the stent maintains the patency of at least one of the esophagus, trachea, bronchial vessels, arteries, veins, biliary vessels and other similar passageways.
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35. The stent of claim 1, wherein the material particles include at least one of a biodegradable or biocorrosive metal or alloy based on at least one of magnesium or zinc, or an alloy comprising at least one of Mg, Ca, Fe, Zn, Al, W, Ln, Si, or Y.
Specification