BIOINTERFACE WITH MACRO- AND MICRO-ARCHITECTURE
First Claim
1. An implantable device, comprising:
- an implantable body; and
a biointerface membrane covering at least a portion of the body, wherein the biointerface comprises;
a macro-architecture defining a plurality of interconnected cavities that are greater than or equal to about 20 microns in at least one dimension; and
a micro-architecture located within at least some of the cavities of the macro-architecture, wherein the micro-architecture has a nominal cavity size of less than or equal to about 20 microns.
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Accused Products
Abstract
Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
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Citations
17 Claims
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1. An implantable device, comprising:
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an implantable body; and a biointerface membrane covering at least a portion of the body, wherein the biointerface comprises; a macro-architecture defining a plurality of interconnected cavities that are greater than or equal to about 20 microns in at least one dimension; and a micro-architecture located within at least some of the cavities of the macro-architecture, wherein the micro-architecture has a nominal cavity size of less than or equal to about 20 microns. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An implantable device, comprising:
- an implantable body and a biointerface membrane located over at least a portion of the implantable body, wherein the biointerface membrane comprises a macro-architecture and a micro-architecture, wherein the macro-architecture and the micro-architecture are co-continuous and interconnected, wherein the macro-architecture and the micro-architecture are configured and arranged to promote vascularization within the biointerface membrane and to interfere with barrier cell layer formation, and wherein the biointerface membrane is configured to facilitate long-term analyte transport in vivo.
- View Dependent Claims (15)
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16. An implantable device, comprising:
- an implantable body and a biointerface membrane located over at least a portion of the implantable body, wherein the biointerface comprising comprises;
a first architecture comprising cavities configured and arranged to facilitate ingrowth of invasive cells and vascular tissue into the biointerface membrane; and a second architecture comprising cavities configured and arranged to facilitate ingrowth of invasive cells into the biointerface membrane while not facilitating ingrowth of vascular tissue. - View Dependent Claims (17)
- an implantable body and a biointerface membrane located over at least a portion of the implantable body, wherein the biointerface comprising comprises;
Specification