TRANSITION METAL COMPLEXES WITH (PYRIDYL)IMIDAZOLE LIGANDS

• US 20080197026A1
• Filed: 10/31/2007
• Published: 08/21/2008
• Est. Priority Date: 05/11/2001
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories)
• Inventors: HELLER, ADAM, MAO, FEI
• Granted Patent: US 8,070,934 B2
• Time in Patent Office: Days
• US Class Current: 205/782
• CPC Class Codes: C07F 1/005 without C-Metal linkages
• CPC Class Codes: C07F 15/0026 without a metal-carbon linkage

Abstract

Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme-based electrochemical sensors. The transition metal complexes include substituted or unsubstituted (pyridyl)imidazole ligands. Transition metal complexes attached to polymeric backbones are also described.

Claims

1. A transition metal complex having the formula:

2. The transition metal complex of claim 1 having the following formula:

3. The transition metal complex of claim 2, wherein said transition metal complex acts as a redox mediator in an electrochemical biosensor.

4. A kit for monitoring the level of an analyte in biological fluid, comprising

an electrochemical sensor,

wherein said electrochemical sensor comprises the transition metal complex of claim 2, and

wherein said transition metal complex acts as a redox mediator.

5. A method for monitoring the concentration of an analyte in biological fluid, comprising

measuring the concentration of an analyte with an electrochemical biosensor;

wherein said biosensor comprises the transition metal complex of claim 2, and

wherein said transition metal complex acts as a redox mediator in said biosensor.

6. The method of claim 4 wherein the analyte is glucose.

7. The method of claim 4 wherein the analyte is a ketone.

8. The transition metal complex of claim 1 having the following formula:

9. The transition metal complex of claim 8, wherein said transition metal complex acts as a redox mediator in an electrochemical biosensor.

10. A kit for monitoring the level of an analyte in biological fluid, comprising

an electrochemical sensor,

wherein said electrochemical sensor comprises the transition metal complex of claim 8, and

wherein said transition metal complex acts as a redox mediator.

11. A method for monitoring the concentration of an analyte in biological fluid, comprising

measuring the concentration of an analyte with an electrochemical biosensor;

wherein said biosensor comprises the transition metal complex of claim 8, and

wherein said transition metal complex acts as a redox mediator in said biosensor.

12. The method of claim 11 wherein the analyte is glucose.

13. The method of claim 11 wherein the analyte is a ketone.