BLISTER PACKAGES WITH FRAMES FOR DRY POWDER DRUG CONTAINMENT
First Claim
Patent Images
1. A multi-dose blister package adapted for use in an inhaler, comprising:
- a frame member having a plurality of spaced apart apertures;
a ceiling having a corresponding plurality of spaced apart projections, the ceiling disposed under the frame member and oriented relative to the frame member so that a respective ceiling projection extends through and rises above a respective frame aperture;
a flexible floor underlying and attached to the ceiling, wherein the ceiling and floor define a plurality of spaced apart sealed blisters; and
a quantity of dry powder held in at least some of the blisters,wherein the frame member has a thickness that is at least five times greater than that of the ceiling and floor.
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Abstract
Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.
139 Citations
18 Claims
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1. A multi-dose blister package adapted for use in an inhaler, comprising:
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a frame member having a plurality of spaced apart apertures; a ceiling having a corresponding plurality of spaced apart projections, the ceiling disposed under the frame member and oriented relative to the frame member so that a respective ceiling projection extends through and rises above a respective frame aperture; a flexible floor underlying and attached to the ceiling, wherein the ceiling and floor define a plurality of spaced apart sealed blisters; and a quantity of dry powder held in at least some of the blisters, wherein the frame member has a thickness that is at least five times greater than that of the ceiling and floor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An inhaler with a multi-dose blister package, comprising:
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an inhaler body; and a circular blister package held in the inhaler body, wherein the blister package comprises; a frame member having a plurality of spaced apart apertures; a flexible ceiling; a frame member configured to hold blisters having a flexible floor and flexible ceiling that define a plurality of spaced apart sealed blisters, wherein the frame member has a thickness that is at least five times greater than that of the ceiling and floor; and a quantity of dry powder held in at least some of the blisters, wherein the blister package has a first set of circumferentially spaced apart concentric blisters and a second set of circumferentially spaced apart concentric blisters, and wherein the second set of blisters reside radially spaced apart a distance from the first set of blisters. - View Dependent Claims (18)
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Specification