DEVICES AND METHODS FOR SELECTIVELY LYSING CELLS

• US 20080197517A1
• Filed: 06/29/2007
• Published: 08/21/2008
• Est. Priority Date: 12/02/2005
• Status: Abandoned Application

• Current Assignee: Ulthera Inc. (Merz Pharma GmbH & Company Kgaa)
• Original Assignee: Cabochon Aesthetics, Inc. (Merz Pharma GmbH & Company Kgaa)
• Inventors: Merchant, Adnan I., Deem, Mark E.
• Application Number:
  US11/771,951
• Publication Number:
  US 20080197517A1
• Time in Patent Office: Days
• US Class Current: 261/77
• CPC Class Codes: A61B 2017/00747 Dermatology
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation
• CPC Class Codes: A61N 2007/0008 Destruction of fat cells
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A device for generating microbubbles in a gas and liquid mixture and injection device, the device comprising: a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; a needle array removably attached to the housing and in fluid connection with the mixing chamber, the needle array including at least one needle; and at least one pressure sensor for measuring tissue apposition pressure, the pressure sensor being mounted on one of the housing and the needle array.

Claims

1. A device for generating microbubbles in a gas and liquid mixture and injection device, said device comprising:

a housing defining a mixing chamber;

means for mixing solution contained in said mixing chamber to generate microbubbles in the solution;

a needle array removably attached to the housing and in fluid connection with said mixing chamber, said needle array including at least one needle; and

at least one pressure sensor for measuring tissue apposition pressure, said pressure sensor being mounted on one of the housing and the needle array.

2. The device of claim 1, deployment of said at least one needle is inhibited if a measured apposition pressure values falls beneath an initial threshold value or exceeds a secondary threshold value.

3. The device of claim 1, wherein the at least one sensor comprising at least two said pressure sensors, wherein deployment of said at least one needle is inhibited if a difference in measured apposition pressure values between any two sensors exceeds a threshold value.

4. The device of claim 3, deployment of said at least one needle is inhibited if a measured apposition pressure values falls beneath an initial threshold value or exceeds a secondary threshold value.

5. The device of claim 1, wherein said at least one needle comprise a through-bore having a texture encouraging the creation of microbubbles.