Methods for Identifying Risk of Type II Diabetes and Treatments Thereof
First Claim
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1. A method for identifying a subject at risk of type II diabetes, which comprises detecting the presence or absence of one or more polymorphic variations associated with type II diabetes in a nucleic acid sample from a subject, wherein the one or more polymorphic variations are detected in a nucleotide sequence in SEQ ID NO:
- 1 or a substantially identical sequence thereof, or a fragment of the foregoing;
whereby the presence of the polymorphic variation is indicative of the subject being at risk of type II diabetes.
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Accused Products
Abstract
Provided herein are methods for identifying a risk of type II diabetes in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating type II diabetes, and therapeutic and preventative methods applicable to type II diabetes. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.
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Citations
56 Claims
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1. A method for identifying a subject at risk of type II diabetes, which comprises detecting the presence or absence of one or more polymorphic variations associated with type II diabetes in a nucleic acid sample from a subject, wherein the one or more polymorphic variations are detected in a nucleotide sequence in SEQ ID NO:
- 1 or a substantially identical sequence thereof, or a fragment of the foregoing;
whereby the presence of the polymorphic variation is indicative of the subject being at risk of type II diabetes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 1 or a substantially identical sequence thereof, or a fragment of the foregoing;
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10. A method for identifying a polymorphic variation associated with type II diabetes proximal to an incident polymorphic variation associated with type II diabetes, which comprises:
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identifying a polymorphic variation proximal to the incident polymorphic variation associated with type II diabetes, wherein the polymorphic variation is detected in a nucleotide sequence in SEQ ID NO;
1 or a substantially identical sequence thereof, or a fragment of the foregoing;determining the presence or absence of an association of the proximal polymorphic variant with type II diabetes. - View Dependent Claims (11, 12, 13, 14, 15)
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- 16. An isolated nucleic acid which comprises a cytosine at a position corresponding to position of 66794 in SEQ ID NO:
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19. An isolated polypeptide which comprises an amino acid sequence identical to or substantially identical to the amino acid sequence of SEQ ID NO:
- 4, or a fragment thereof, wherein the polypeptide or fragment thereof comprises a histidine corresponding to position 914 in SEQ ID NO;
4, an arginine corresponding to position 924 in SEQ ID NO;
4, or a histidine corresponding to position 914 in SEQ ID NO;
4 and an arginine corresponding to position 924 in SEQ ID NO;
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- 4, or a fragment thereof, wherein the polypeptide or fragment thereof comprises a histidine corresponding to position 914 in SEQ ID NO;
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20-42. -42. (canceled)
- 43. A method for treating type II diabetes, which comprises administering to a subject in need thereof a molecule that specifically interacts with an EPHA3 polypeptide, whereby the molecule is administered in an amount effective to treat the type II diabetes.
- 48. A composition comprising a cell from a subject having type II diabetes or at risk of type II diabetes and an antibody that specifically binds to a protein, polypeptide or peptide encoded by a nucleotide sequence identical to or 90% or more identical to a nucleotide sequence in SEQ ID NO:
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52. A composition comprising a cell from a subject having type II diabetes or at risk of type II diabetes and a RNA, DNA, PNA or ribozyme molecule comprising a nucleotide sequence identical to or 90% or more identical to a portion of a nucleotide sequence in SEQ ID NO:
- 1-3, or a complementary sequence of the foregoing.
- View Dependent Claims (53, 54)
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55. A method of genotyping a nucleic acid which comprises determining the nucleotide corresponding to position 66794 of SEQ ID NO:
- 1 in the nucleic acid.
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56-59. -59. (canceled)
Specification