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PROBES AND METHODS FOR DETECTION OF PATHOGENS AND ANTIBIOTIC RESISTANCE

  • US 20080199863A1
  • Filed: 05/01/2007
  • Published: 08/21/2008
  • Est. Priority Date: 11/01/2004
  • Status: Active Grant
First Claim
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1. A pair of oligonucleotide probes, comprising a capture probe and a detector probe, each of which is 10-35 bases in length, and that specifically hybridize under highly stringent conditions to a target capture region and a target detector region, respectively, of bacterial ribosomal RNA (rRNA), wherein the target capture region and target detector region are, or are fully complementary to, nucleic acid molecules corresponding to, a pair of sequences selected from the group consisting of:

  • (a) SEQ ID NO;

    22, target capture region of P. mirabilis, andSEQ ID NO;

    23, target detector region of P. mirabilis, (b) SEQ ID NO;

    24, target capture region of E. faecalis, andSEQ ID NO;

    25, target detector region of E. faecalis, (c) SEQ ID NO;

    26, target capture region of K. pneumoniae, andSEQ ID NO;

    27, target detector region of K. pneumoniae, and(d) SEQ ID NO;

    28, target capture region of E. coli, andSEQ ID NO;

    29, target detector region of E. coli, (e) SEQ ID NO;

    30, target capture region of Enterobacteriaceae, andSEQ ID NO;

    31, target detector region of Enterobacteriaceae;

    (f) SEQ ID NO;

    32, target capture region of P. aeruginosa, andSEQ ID NO;

    33, target detector region of P. aeruginosa;

    (g) SEQ ID NO;

    34, target capture region of Acinetobacter baumani, andSEQ ID NO;

    35, target detector region of Acinetobacter baumani;

    (h) SEQ ID NO;

    36, target capture region of Enterobacter aerogenes, andSEQ ID NO;

    37, target detector region of Enterobacter aerogenes;

    (i) SEQ ID NO;

    38, target capture region of Serratia marcescens, andSEQ ID NO;

    39, target detector region of Serratia marcescens;

    (j) SEQ ID NO;

    40, target capture region of Stenotrophomonas maltophilia, andSEQ ID NO;

    41, target detector region of Stenotrophomonas maltophilia; and

    (k) SEQ ID NO;

    42, universal bacterial target capture region, andSEQ ID NO;

    43, universal bacterial target detector region.

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