Chemical Target-Binding Compositions
First Claim
1. A pharmaceutical composition comprising a biocompatible binding component comprising a binding moiety capable of reversibly binding with a chemical target, wherein the pharmaceutical composition is capable of regulating the concentration of the chemical target in a physiological fluid of a patient.
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Accused Products
Abstract
Herein is described compositions and methods for modulating and regulating the concentration of a chemical target in an organism or in an ecosystem. In one embodiment, the concentration is regulated such that it is maintained below or above a certain threshold, thus avoiding toxic or harmful effects of the chemical target. The described compositions may, for example, be implanted in a human body or placed in the ecosystem. The compositions comprise binding moieties that reversibly bind to a chemical target in the organism or ecosystem. The binding capacity and the binding constants for a chemical target are designed such that the composition maintains the concentration of the chemical target substantially within a beneficial range of concentrations.
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Citations
74 Claims
- 1. A pharmaceutical composition comprising a biocompatible binding component comprising a binding moiety capable of reversibly binding with a chemical target, wherein the pharmaceutical composition is capable of regulating the concentration of the chemical target in a physiological fluid of a patient.
- 44. A pharmaceutical composition for treating diabetes comprising a biocompatible binding component capable of reversibly binding glucose, wherein the pharmaceutical composition is in a dosage form capable of contacting the physiological fluid of a patient suffering from diabetes for a predetermined length of time.
- 54. A method for regulating the concentration of glucose in the blood of a patient comprising contacting the blood of the patient with a pharmaceutical composition comprising a therapeutic amount of a biocompatible binding component capable of reversibly binding glucose.
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65. A method for regulating the concentration of a chemical target in a physiological fluid of a patient, the method comprising:
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(a) administering to the patient a composition capable of binding to the chemical target; and (b) administering to the patient the chemical target.
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- 66. A composition for regulating the concentration of a chemical target in an aqueous environment of an ecosystem, comprising a binding component comprising a binding moiety capable of reversibly binding with a chemical target, wherein the binding constant of the binding moiety is complementary to the beneficial range of concentrations for the chemical target in the aqueous environment.
Specification