METHOD AND APPARATUS FOR CONTROL OF SKIN PERFUSION FOR INDIRECT GLUCOSE MEASUREMENT
First Claim
1. A noninvasive method of measuring a tissue analyte, comprising steps of:
- stabilizing optical properties of said tissue at a measurement site;
collecting an analytical signal from the tissue, said collected signal comprising a tissue measurement;
extracting features from the analytical signal indicative of the affect of the target analyte on the probed tissue; and
calculating concentration of said analyte indirectly by application of a calibration model to said features.
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Accused Products
Abstract
A method and apparatus for noninvasive glucose measurement measures glucose indirectly from the natural response of tissue to variations in analyte concentration. The indirect measurement method utilizes factors affected by or correlated with the concentration of glucose, such as refractive index, electrolyte distribution or tissue scattering. Measurement reliability is greatly improved by stabilizing optical properties of the tissue at the measurement site, thus blood perfusion rates at the sample site are regulated. Perfusion is monitored and stabilized by spectroscopically measuring a control parameter, such as skin temperature, that directly affects perfusion. The control parameter is maintained in a range about a set point, thus stabilizing perfusion. Skin temperature is controlled using a variety of means, including the use of active heating and cooling elements, passive devices, such as thermal wraps, and through the use of a heated coupling medium having favorable heat transfer properties.
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Citations
24 Claims
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1. A noninvasive method of measuring a tissue analyte, comprising steps of:
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stabilizing optical properties of said tissue at a measurement site;
collecting an analytical signal from the tissue, said collected signal comprising a tissue measurement;
extracting features from the analytical signal indicative of the affect of the target analyte on the probed tissue; and
calculating concentration of said analyte indirectly by application of a calibration model to said features. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A noninvasive method of measuring a tissue analyte, comprising steps of:
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providing a coupling medium;
heating a portion of said coupling medium;
disposing said heated portion of said coupling medium between a measurement probe and a skin surface at a sampling site;
collecting an analytical signal from the tissue, said collected signal comprising a tissue measurement; and
calculating concentration of said analyte from said tissue measurement. - View Dependent Claims (19, 20, 21, 22, 23, 24)
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Specification