SELF-ADDRESSABLE SELF-ASSEMBLING MICROELECTRONIC SYSTEMS AND DEVICES FOR MOLECULAR BIOLOGICAL ANALYSIS AND DIAGNOSTICS
First Claim
1. A self-addressable electronic device comprising:
- a substrate,a first selectively addressable electrode, the electrode being supported by the substrate,a permeation layer, the permeation layer being disposed adjacent the first selectively addressable electrode,a current source operatively connected to the first selectively addressable electrode, andan attachment layer adjacent the permeation layer.
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Accused Products
Abstract
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micro-machining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.
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Citations
7 Claims
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1. A self-addressable electronic device comprising:
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a substrate, a first selectively addressable electrode, the electrode being supported by the substrate, a permeation layer, the permeation layer being disposed adjacent the first selectively addressable electrode, a current source operatively connected to the first selectively addressable electrode, and an attachment layer adjacent the permeation layer. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification