Free-standing nanowire sensor and method for detecting an analyte in a fluid

• US 20080204048A1
• Filed: 11/17/2006
• Published: 08/28/2008
• Est. Priority Date: 12/03/2002
• Status: Active Grant

• Current Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Original Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Inventors: Peters, Kevin, Williams, R. Stanley, Stasiak, James, McClelland, Paul H., Hackleman, David E., Pease, Grant
• Granted Patent: US 7,833,801 B2
• Time in Patent Office: Days
• US Class Current: 324/679
• CPC Class Codes: G01N 27/3278 involving nanosized elements, e.g. nanogaps or nanoparticles nanopores G01N33/48721; magnetic beads G01N27/745
• CPC Class Codes: Y10T 436/114998 with treatment or replacement of aspirator element [e.g., cleaning, etc.]

Abstract

A sensor device and method for detecting the presence of an analyte in a fluid solution are disclosed. The sensor device system can comprise a substrate and an array of free-standing nanowires attached to the substrate. The array can include individual free-standing nanowires wherein each of the individual free-standing nanowires have a first end and a second end. The first end can, in some embodiments, be attached to the substrate and the second end unattached to the substrate. Such individual free-standing nanowires are configured for electrical communication with other individual free-standing nanowires through the first end. A chip or computer can be electrically coupled to the array of free-standing nanowires for receiving electrical information from the array of free-standing nanowires. In some embodiments a power source can be used to send current through the nanowire array.

Claims

1. A method of detecting the presence of an analyte in a test fluid environment, comprising:

providing a first array of free-standing nanowires that is interactive with an analyte, said first array of free-standing nanowires having individual nanowires that are electrically interactive with one another, said first array of free-standing nanowires being electrically coupled to a chip or computer that is human- or machine-readable;

exposing the first array of free-standing nanowires to a test fluid environment suspected of containing the analyte;

measuring an electrical property provided by the first array of free-standing nanowires upon exposure to the test fluid environment.

2. A method as in claim 1, further comprising the steps of

providing a second array of free-standing nanowires, said second array of free-standing nanowires having individual nanowires that are electrically interactive with one another, said second array of free-standing nanowires being electrically coupled to the chip or computer;

exposing the second array of free-standing nanowires to a control fluid environment;

comparing the electrical property provided by the second array of free-standing nanowires upon exposure a control fluid environment to the electrical property provided by the first array of free-standing nanowires, thereby providing a differential measurement.

3. A method as in claim 2, wherein the second array of free-standing nanowires is also configured to be interactive with the analyte, and wherein the control fluid environment is known to be void of the analyte, or is known to have a fixed concentration of the analyte, thereby providing a basis for the comparing step.

4. A method as in claim 2, wherein the second array of free-standing nanowires is configured to be non-interactive with the analyte, and wherein the control fluid environment and fluid environment are substantially the same fluid composition, thereby providing a basis for the comparing step.

5. A method as in claim 2, wherein the first array of free-standing nanowires is functionalized with a composition interactive with the analyte.

6. A method as in claim 2, wherein the first array of free-standing nanowires is functionalized with an insulating composition.

7. A method as in claim 2, wherein the electrical property of the array of free-standing nanowires is conductance or impedance at a predetermined frequency.

8. A method as in claim 6, wherein the electrical property between the analyte and at least one individual free-standing nanowires is capacitance or impedance at a predetermined frequency.

9. A method of detecting the presence of an analyte in a fluid environment, comprising:

providing a detecting system comprising a first capacitive plate having a first array of free-standing nanowires that is interactive with an analyte, said first array of free-standing nanowires comprising individual nanowires that are electrically interactive with one another, and a second capacitive plate positioned in proximity to the first capacitive plate such electrical communication between the first capacitive plate and the second capacitive plate occurs in the presence of the test fluid environment,

placing the test fluid environment in continuous contact with the first capacitive plate and the second capacitive plate;

applying electrical current to at least one of the first capacitive plate and the second capacitive plate; and

measuring an electrical property passed capacitively between the first capacitive plate and the second capacitive plate.

10. A method as in claim 9, further comprising the steps of:

providing a control system comprising a third capacitive plate and a fourth capacitive plate that are substantially configured the same as the first capacitive plate and the second capacitive plate, respectively, and

placing a control fluid that is known to be void of the analyte in continuous contact with third capacitive plate and the fourth capacitive plate, thereby providing a comparison basis for the measuring step.

11. A method as in claim 9, further comprising the step of:

providing a control system having a third capacitive plate and a fourth capacitive plate that are substantially configured the same as the first capacitive plate and the second capacitive plate, respectively, except that the nanowires of the third and fourth capacitive plates are not interactive with the analyte, and

placing the test fluid in contact with the control system, thereby providing a comparison basis for the measuring step.