Pro-Angiogenic Polymer Scaffolds
First Claim
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1. A pro-angiogenic porous polymer scaffold, said polymer comprising at least 20 mol-% monomeric subunits containing acidic functional groups, said polymer having a porosity of at least 40%, and having interconnected pores.
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Abstract
A pro-angiogenic porous polymer scaffold is disclosed. The polymer has at least 20 mol-% monomeric subunits containing acidic functional groups, and has a porosity of at least 40%. The pores in the scaffold are interconnected. A method of making such a scaffold using a novel adaptation to the traditional solvent casting/particulate leaching technique is also disclosed. The scaffold may be used for tissue regeneration.
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13 Claims
- 1. A pro-angiogenic porous polymer scaffold, said polymer comprising at least 20 mol-% monomeric subunits containing acidic functional groups, said polymer having a porosity of at least 40%, and having interconnected pores.
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10. A method for making a pro-angiogenic porous polymer scaffold, wherein said polymer comprises at least 20 mol-% monomeric subunits containing acidic functional groups, said scaffold having a porosity of at least 40%, and having interconnected pores, said method comprising:
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mixing one or more types of monomers, and an initiator together in a solvent, wherein at least 20 mol-% of said monomers contain an acidic functional group; pouring the mixture over a fused salt bed having a pore size range of 10 to 800 microns; allowing the mixture to polymerize; and leaching the salt out, to yield the porous scaffold. - View Dependent Claims (11)
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