Topical Ungual Formulations
First Claim
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1. A method for the treatment of an ungual condition treatable by a drug in a patient in need thereof, wherein a first preparation of a reducing agent and a second preparation of an oxidizing agent are separately disposed and sequentially administered to the nail of said patient in the order of first preparation followed by second preparation, said drug being disposed in said first preparation said second preparation, or, optionally, in a third preparation, said drug being additional to said reducing and said oxidising agents.
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Abstract
Application of a reducing agent followed by an oxidising agent to a nail substantially increases the permeability thereof, thereby enabling the passage of drugs across the nail.
42 Citations
46 Claims
- 1. A method for the treatment of an ungual condition treatable by a drug in a patient in need thereof, wherein a first preparation of a reducing agent and a second preparation of an oxidizing agent are separately disposed and sequentially administered to the nail of said patient in the order of first preparation followed by second preparation, said drug being disposed in said first preparation said second preparation, or, optionally, in a third preparation, said drug being additional to said reducing and said oxidising agents.
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44. A method for the treatment of an ungual infection of a nail in a patient in need thereof, comprising applying a preparation of a reducing agent to said nail, followed by applying a preparation of an oxidizing agent thereto, said ungual condition being treatable by a drug, said drug being disposed in one of said preparations or in a third preparation.
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45. canceled
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46. A kit comprising a first preparation of a reducing agent and a second preparation of an oxidizing agent separately disposed therein, a drug to treat an ungual condition being disposed in said first preparation, said second preparation, or, optionally, in a third preparation, said drug being additional to said reducing and said oxidizing agents.
Specification