METHODS FOR THE TREATMENT AND PREVENTION OF NEURODEGENERATIVE CONDITIONS

• US 20080207631A1
• Filed: 02/26/2008
• Published: 08/28/2008
• Est. Priority Date: 11/12/1999
• Status: Abandoned Application

• Current Assignee: Wyeth (Pfizer Inc.)
• Original Assignee: Wyeth (Pfizer Inc.)
• Inventors: Moyer, John A., Childers, Wayne E., Barrett, James E., Abou-Gharbia, Magid A.
• Application Number:
  US12/037,442
• Publication Number:
  US 20080207631A1
• Time in Patent Office: Days
• US Class Current: 514/252.14
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system

Abstract

Adatanserin is useful for treating neurodegenerative disorders, chronic pain, and other disorders associated with dysfunctional glutamate release. Methods of treating the same comprise administering a therapeutically effective amount of adatanserin or a pharmaceutical salt thereof, to a patient in need of said treatment.

Claims

1. A method for treating neurodegenerative disorders comprising administering a therapeutically effective amount of adatanserin or a pharmaceutical salt thereof, to a patient in need of said treatment.

2. The method of claim 1 wherein the neurodegenerative disorder is chronic.

3. The method of claim 2 wherein the neurodegenerative disorder is Parkinson'"'"'s Disease.

4. The method of claim 2 wherein the neurodegenerative disorder is AIDS dementia.

5. The method of claim 2 wherein the neurodegenerative disorder is Amyotrophic Lateral Sclerosis.

6. The method of claim 2 wherein the neurodegenerative disorder is retinal disease.

7. The method of claim 2 wherein the neurodegenerative disorder is epilepsy.

8. The method of claim 1 wherein the neurodegenerative disorder is acute.

9. The method of claim 8 wherein the neurodegenerative disorder is stroke.

10. The method of claim 9 wherein stroke is acute thromboembolic stroke.

11. The method of claim 9 wherein stroke is focal ischemia.

12. The method of claim 9 wherein stroke is global ischemia.

13. The method of claim 9 wherein stroke is transient ischemic attack.

14. The method of claim 8 wherein the neurodegenerative disorder is ischemia resulting from a surgical technique involving prolonged halt of blood flow to the brain.

15. The method of claim 8 wherein the neurodegenerative disorder is head trauma.

16. The method of claim 8 wherein the neurodegenerative disorder is spinal trauma.

17. The method of claim 8 wherein the neurodegenerative disorder is hypoxia.

18. The method of claim 17 wherein the hypoxia is fetal hypoxia.

19. A method of treating chronic pain comprising administering a therapeutically effective amount of adatanserin to a patient in need thereof.

20. The method of claim 19 wherein the pain is diabetic peripheral neuropathy.

21. The method of claim 19 wherein the pain is selected from fibromyalgia, postherpetic neuralgia, and reflex sympathetic dystrophy.

22. A method of neuroprotection comprising administering a therapeutically effective amount of adatanserin to a patient in need thereof.