Method of measuring skin conductance, method of analyzing component concentration, skin conductance measuring apparatus, and component concentration analyzer

• US 20080208024A1
• Filed: 02/28/2008
• Published: 08/28/2008
• Est. Priority Date: 02/28/2007
• Status: Abandoned Application

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: Maekawa, Yasunori, Okada, Seiki, Hagino, Kei, Asano, Kaoru
• Application Number:
  US12/074,198
• Publication Number:
  US 20080208024A1
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

The present invention provides a method of measuring skin conductance which can obtain an accuracy measurement result, comprising the steps of: supplying a low conductivity medium as a medium for holding tissue fluid that contains a predetermined component of a subject to a medium containing part; disposing the medium containing part on an extraction region of a skin of the subject; extracting tissue fluid through the extraction region into the low conductivity medium within the medium containing part; supplying electric power between a first electrode for supplying electric power to the extraction region and a second electrode for supplying electric power to the skin outside the extraction region; and measuring the conductance of the extraction region based on the electric power supplied between the first electrode and second electrode. A method of analyzing a component concentration, a skin conductance measuring apparatus, and a component concentration analyzer are also disclosed.

Claims

1. A method of measuring skin conductance, comprising the steps of:

supplying a low conductivity medium as a medium for holding tissue fluid that contains a predetermined component of a subject to a medium containing part;

disposing the medium containing part on an extraction region of a skin of the subject;

extracting the tissue fluid through the extraction region into the low conductivity medium within the medium containing part;

supplying electric power between a first electrode for supplying electric power to the extraction region and a second electrode for supplying electric power to the skin outside the extraction region; and

measuring the conductance of the extraction region based on the electric power supplied between the first electrode and second electrode.

2. The method of measuring skin conductance according to claim 1, wherein the resistivity of the low conductivity medium in the medium containing part is 1.67 KΩ

·

cm or greater when the extraction of the tissue fluid begins.

3. The method of measuring skin conductance according to claim 1, wherein the low conductivity medium is purified water.

4. A method of analyzing a component concentration, comprising the steps of:

supplying a low conductivity medium as a medium for holding tissue fluid that contains a predetermined component of a subject to a medium containing part;

disposing the medium containing part on an extraction region of the skin of the subject;

extracting the tissue fluid through the extraction region into the low conductivity medium within the medium containing part;

supplying electric power between a first electrode for supplying electric power to the extraction region and a second electrode for supplying electric power to the skin outside the extraction region;

measuring a value that corresponds to the amount of the predetermined component contained in the tissue fluid extracted through the extraction region into the low conductivity medium; and

calculating the concentration of the predetermined component in the tissue fluid based on a energization result of the electric power supplied between the first electrode and the second electrode, and the value obtained at the measuring step.

5. The method of analyzing a component concentration according to claim 4, wherein the calculating step is performed so as to measure a conductance of the extraction region as the energization result.

6. The method of analyzing a component concentration according to claim 5, wherein the conductance is measured when the ions in the low conductivity medium are in a substantially homogeneous condition after the extracting step.

7. A skin conductance measuring apparatus, comprising:

a medium containing part, desposed on an extraction region of the skin of a subject, to accommodate a low conductivity medium for holding tissue fluid that contains a predetermined component of the subject;

a first electrode for supplying electric power to the extraction region;

a second electrode for supplying electric power to a first region outside of the extraction region of the skin of the subject;

a power source for supplying electric power to the first electrode and the second electrode; and

a conductance measuring part for measuring the conductance of the extraction region based on the electric power supplied from the power source to the first electrode and the second electrode.

8. A component concentration analyzer, comprising:

a medium containing part, desposed on an extraction region of the skin of a subject, to accommodate a low conductivity medium for holding tissue fluid that contains a predetermined component of the subject;

a first electrode for supplying electric power to the extraction region;

a second electrode for supplying electric power to the skin outside the extraction region;

a power source for supplying electric power to the first electrode and the second electrode;

a energization result measuring part for measuring a energization result by supplying electric power from the power source to the first electrode and second electrode;

a component amount measuring part for measuring a value corresponding to the amount of a predetermined component contained in the tissue fluid extracted through the extraction region into a low conductivity medium in the medium containing part; and

an analyzing part for calculating the concentration of the predetermined component in the tissue fluid based on the energization result and the value corresponding to the amount of the predetermined component.

9. A skin conductance measuring apparatus, comprising:

a first electrode for supplying electric power to a position corresponding to an extraction region which is a skin of a subject performed a skin permeability facilitating treatment for extracting tissue fluid that contains a predetermined component;

a second electrode for supplying electric power to a position corresponding to a region which is the skin of the subject outside the extraction region;

a power source for applying an alternating current as electric power to the skin of the subject through the first electrode and the second electrode;

an electrical information obtaining part for obtaining electrical information by applying the alternating current from the power source to the skin of the subject; and

a calculating part for calculating the conductance of the skin of the subject based on the electrical information.

10. The skin conductance measuring apparatus according to claim 9, further comprising a tissue fluid retention part for retaining the tissue fluid.

11. The skin conductance measuring apparatus according to claim 9, wherein the power source is capable of applying a direct current to the skin of the subject through the first electrode and the second electrode.

12. The skin conductance measuring apparatus according to claim 9, wherein the power source is capable of applying a current composed of an overlaid alternating current and direct current to the skin of the subject through the first electrode and the second electrode..

13. The skin conductance measuring apparatus according to claim 10, wherein the tissue fluid retention part includes a retention substance for retaining the tissue fluid.

14. The skin conductance measuring apparatus according to claim 13, wherein the retention substance is a non-conductive medium.

15. The skin conductance measuring apparatus according to claim 9, wherein the extraction region is the skin of the subject in which a micropore is formed as the skin permeability facilitating treatment.

16. The skin conductance measuring apparatus according to claim 9, wherein the frequency of the alternating current is greater than 100 Hz and less than 6000 Hz.

17. The skin conductance measuring apparatus according to claim 9, wherein the conductance of the skin includes the conductance of the extraction region.

18. The skin conductance measuring apparatus according to claim 9, wherein electrical information includes the impedance of the extraction region.

19. The skin conductance measuring apparatus according to claim 9, wherein the predetermined component includes glucose.

20. The skin conductance measuring apparatus according to claim 9, further comprising a reference electrode for measuring a voltage applied between the second electrode and the extraction region.

21. A component concentration analyzer, comprising:

a first electrode for supplying electric power to a position corresponding to an extraction region which is a skin of a subject performed a skin permeability facilitating treatment for extracting tissue fluid that contains a predetermined component;

a second electrode for supplying electric power to a position corresponding to a region which is the skin of the subject outside the extraction region;

a tissue fluid retention part for retaining the tissue fluid extracted from the extraction region. a power source for applying an alternating current as electric power to the skin of the subject through the first electrode and second electrode;

an electrical information obtaining part for obtaining electrical information that is obtained by applying an alternating current from the power source to the skin of the subject;

a calculating part for calculating the conductance of the skin of the subject based on the electrical information;

a component amount obtaining part for obtaining a value corresponding to the amount of the predetermined component in the tissue fluid retention part; and

a component concentration obtaining part for calculating the concentration of the predetermined component in the tissue fluid based on the value obtained by the component amount obtaining part, and the conductance of the extraction region calculated by the calculating part.

22. A method of measuring skin conductance, comprising the steps of:

performing a skin permeability facilitating treatment on the extraction region of the skin of a subject; and

calculating the conductance of the skin based on electrical information obtained by applying an alternating current to the extraction region and a region outside the extraction region of the skin of the subject.

23. A method of analyzing a component concentration, comprising the steps of:

performing a skin permeability facilitating treatment on the extraction region of the skin of a subject;

extracting tissue fluid which contains a predetermined component through the extraction region of the skin of the subject;

obtaining a value corresponding to an amount of the predetermined component of the tissue fluid extracted by the extracting step;

calculating a conductance of the skin based on electrical information obtained by applying an alternating current to the extraction region and a region outside the extraction region of the skin of the subject; and

analyzing the concentration of the predetermined component contained in the tissue fluid of the subject based on the value obtained by the obtaining step and the conductance of the skin obtained by the calculating step.

24. The method of analyzing a component concentration of claim 23, wherein the extracting step and the calculating step are a step of calculating the conductance of the skin based on electrical information obtained using an alternating current while extracting tissue fluid which contains the predetermined component through the extraction region of the skin of the subject using a direct current, by applying a current composed of an overlaid alternating current and direct current to the skin of the subject.