Method for treating myocardial infarction

• US 20080208274A1
• Filed: 04/25/2008
• Published: 08/28/2008
• Est. Priority Date: 03/23/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Pastore, Joseph M., Zhu, Qingsheng, Salo, Rodney W.
• Granted Patent: US 8,050,761 B2
• Time in Patent Office: Days
• US Class Current: 607/11
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

Claims

1. A method for treating a patient with myocardial infarction, comprising:

identifying an infarcted area in the left ventricle of the patient;

implanting a lead having one or more pacing electrodes in a cardiac vein so that the pacing electrode or electrodes are disposed adjacent to the infarcted area;

delivering pacing pulses to one or more sites in proximity to the infarcted area with a selected pacing mode, wherein the pacing pulses are delivered in a manner that pre-excites the site or sites in proximity to the infarcted area relative to other areas of the ventricle;

wherein the selected pacing mode is an AV sequential or atrial tracking mode that delivers a pre-excitation pace or paces to the infarcted area of the left ventricle upon expiration of a specified AV delay interval subsequent to an atrial event;

evaluating hemodynamic performance by measuring a variable selected from dP/dt, pulse pressure, and left ventricular systolic pressure; and

,

optimizing one or more pacing parameters including the AV delay interval by selecting values which result in a minimum LVEDP without adversely affecting hemodynamic performance.

3. The method of claim 1 wherein pacing parameters are selected as values which maximize synchrony between the septum and lateral wall of the heart.

4. The method of claim 1 wherein the pacing pulses are delivered in accordance with a bradycardia pacing mode.

5. The method of claim 4 wherein the pacing mode is an inhibited demand ventricular pacing mode.

6. The method of claim 5 wherein the pacing mode is an atrial tracking mode.

7. The method of claim 1 wherein the selected pacing mode is a biventricular pacing mode.

8. The method of claim 7 wherein the optimized pacing parameters include the biventricular offset interval.

9. The method of claim 8 wherein the biventricular offset interval is optimized to minimize LVEDP without adversely affecting hemodynamic performance.

10. The method of claim 1 wherein the biventricular offset interval is selected as a value which maximizes synchrony between the septum and lateral wall of the heart.

14. The method of claim 1 wherein paces are delivered to multiple sites in proximity to the infarcted area simultaneously.

15. The method of claim 1 wherein paces are delivered to multiple sites in proximity to the infarcted area in an order defined by a specified pulse output sequence.

16. The method of claim 1 wherein the pacing pulse are delivered to multiple sites via a patch having electrodes that circumscribe a region in proximity to the infarcted area.

20. The method of claim 1 wherein the pacing pulses are delivered to one or multiple sites via electrodes that are contained within the infarcted area.

2. (canceled)

11-12. -12. (canceled)

17-19. -19. (canceled)