SYSTEMS AND METHODS FOR NEUROMODULATION USING PRE-RECORDED WAVEFORMS

• US 20080208284A1
• Filed: 11/20/2007
• Published: 08/28/2008
• Est. Priority Date: 04/13/2005
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: IntElect Medical, Inc. (Boston Scientific Corporation), Cleveland Clinic Foundation
• Inventors: Machado, Andre, Rezai, Ali, Carlton, Keith
• Granted Patent: US 8,112,154 B2
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/1106 to assess neuromuscular blockade, e.g. to estimate depth of anaesthesia
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4047 afferent nerves, i.e. nerves that relay impulses to the central nervous system
• CPC Class Codes: A61B 5/4052 efferent nerves, i.e. nerves that relay impulses from the central nervous system
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36071 Pain

Abstract

Methods for neuromodulation using waveform signals. In certain embodiments, an input waveform is obtained from a signal source site in a source subject and an output waveform is applied to a target site in a target subject. The source subject is a human or animal and the signal source site is in the nervous system, including the brain. The source subject and target subject are the same subjects or different subjects. The output waveform is identical to the input waveform or derived from the input waveform. In some embodiments, the output waveform is modified in response to physiologic feedback. Also provided are systems for neuromodulation using waveform signals.

Claims

1. A method for neuromodulation to treat paralysis or weakness due to a cortical injury, comprising:

recording an input waveform from a first site in the nervous system in a first subject, wherein the first site is selected from the group consisting of;

motor cortex, premotor cortex, thalamus, red nucleus, olivary nucleus, and dentate nucleus; and

applying an output waveform to a second site in the nervous system in a second subject, wherein the second site is selected from the group consisting of;

motor cortex, premotor cortex, thalamus, red nucleus, olivary nucleus, and dentate nucleus;

wherein the output waveform is identical to the input waveform or derived from the input waveform.

2. The method of claim 1, wherein the first subject and second subject are different subjects.

3. The method of claim 2, wherein the first subject is a non-human primate.

4. The method of claim 2, wherein the second site in the nervous system anatomically corresponds to the first site in the nervous system.

5. The method of claim 2, wherein the second site in the nervous system anatomically corresponds to a structure that is neurologically distal to the first site in the nervous system.

6. The method of claim 1, wherein the first subject and second subject are the same subject.

7. The method of claim 6, wherein the second site is the corresponding anatomic structure that is contralateral to the first site.

8. The method of claim 7, wherein the first site is healthy or at least partially functioning, and wherein the second site is diseased.

9. The method of claim 6, wherein the second brain site is neurologically distal from the first brain site.

10. The method of claim 1, further comprising positioning an electrode at the second site, and applying the output waveform through the electrode.

11. The method of claim 1, further comprising modifying the input waveform to generate the output waveform.

12. The method of claim 1, further comprising sensing a body activity.

13. The method of claim 12, further comprising, in response to the body activity sensed, modifying the output waveform.

14. The method of claim 13, wherein the body activity being sensed is limb motion.

15. The method of claim 1, wherein the input waveform is recorded while the first subject is performing a task.

16. The method of claim 15, wherein the task is a forelimb or hindlimb motor task.

17. A neurostimulation system comprising:

memory that stores waveform data for at least one waveform;

a playback system that provides an output waveform based on the waveform data in the memory;

a sensor for sensing a bodily activity; and

a controller in communication with the sensor, wherein, in response to the bodily activity sensed, the controller controls the output waveform.

18. The system of claim 17, wherein the waveform data stored in memory is associated with specific tasks.

19. The system of claim 18, wherein the tasks are forelimb or hindlimb motor tasks.

20. The system of claim 17, wherein the sensor is a motion sensor.

21. The system of claim 18, further comprising an implantable pulse generator.

22. The system of claim 18, further comprising a stimulation electrode, and wherein the output waveform is applied through the stimulation electrode.