Systems and Methods For Placement of Valve Prosthesis System
First Claim
1. A method of implanting a valve prosthesis with respect to an anatomical annulus, the method comprising:
- providing, in a vicinity of the anatomical annulus;
a valve prosthesis including a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring;
a first elongate element terminating at the valve prosthesis and manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring; and
a second elongate element terminating at the valve prosthesis and manipulable by an operator to remotely advance the valve prosthesis downward into the anatomical annulus;
manipulating the first elongate element to remotely rotate the positioning elements relative to the flexible ringmanipulating the second elongate element to remotely advance the valve prosthesis into the anatomical annulus to assume a position within the anatomical annulus suitable for supporting post-implantation function of the valve prosthesis in situ; and
manipulating the first elongate element to remotely further rotate the positioning element relative to the flexible ring to cause the positioning element to engage tissue associated with the anatomical annulus for maintaining the post-implantation position of the valve prosthesis in situ.
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Accused Products
Abstract
Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities. The placement systems and methods permit remote manipulation and positioning of the valve prosthesis such that desirable placement relative to anatomical structures, e.g., the heart annulus, may be achieved. The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring. A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus. The second elongate element may be manipulated to remotely advance the valve prosthesis into the anatomical annulus to assume a position for supporting post-implantation function of the valve prosthesis in situ. The first elongate element may be further manipulated to remotely rotate the positioning element relative to the flexible ring to cause the positioning element to engage tissue associated with the anatomical annulus and to thereby maintain the post-implantation position of the valve prosthesis in situ. Methods for valve prosthesis deployment are also provided.
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Citations
25 Claims
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1. A method of implanting a valve prosthesis with respect to an anatomical annulus, the method comprising:
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providing, in a vicinity of the anatomical annulus; a valve prosthesis including a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring; a first elongate element terminating at the valve prosthesis and manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring; and a second elongate element terminating at the valve prosthesis and manipulable by an operator to remotely advance the valve prosthesis downward into the anatomical annulus; manipulating the first elongate element to remotely rotate the positioning elements relative to the flexible ring manipulating the second elongate element to remotely advance the valve prosthesis into the anatomical annulus to assume a position within the anatomical annulus suitable for supporting post-implantation function of the valve prosthesis in situ; and manipulating the first elongate element to remotely further rotate the positioning element relative to the flexible ring to cause the positioning element to engage tissue associated with the anatomical annulus for maintaining the post-implantation position of the valve prosthesis in situ. - View Dependent Claims (2)
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3. A delivery system for percutaneous delivery of a valve prosthesis, comprising:
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a valve prosthesis including a flexible ring, a plurality of leaflet members mounted with respect to the flexible ring, and a plurality of positioning elements (i) mounted with respect to the flexible ring for engaging tissue at an anatomical location, and (ii) rotatable relative to the flexible ring to facilitate delivery and implantation of the valve prosthesis; a first elongate element defining an internal lumen for accommodating a guide wire, the first elongate element being detachably mounted with respect to the valve prosthesis and manipulable by an operator to remotely position the valve prosthesis with respect to tissue at the anatomical location; one or more second elongate elements manipulable by an operator to remotely rotate the plurality of positioning elements with respect to the flexible ring; and a third elongate element manipulable by an operator to remotely decouple the first elongate element from the valve prosthesis after implantation thereof; wherein for purposes of being so manipulated, each of the second elongate element and the third elongate element is adapted to translate with respect to the first elongate element when at least partially disposed together with the first elongate element within a central lumen of a delivery catheter. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A tool for facilitating percutaneous delivery of a valve prosthesis to an anatomical location, comprising:
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a body defining a longitudinal axis, a distal end disposed on the longitudinal axis, and a proximal end disposed on the longitudinal axis opposite the distal end; a first actuator mounted with respect to the body at one of the distal end thereof and the proximal end thereof, the first actuator being configured to receive and engage a first elongate element manipulable to remotely rotate a positioning element associated with a valve prosthesis, and being reciprocally actuatable with respect to the body for manipulating the first elongate element by causing the first elongate element to translate with respect to a delivery tube along the longitudinal axis; and a second actuator mounted with respect to the body at the other of the distal end thereof and the proximal end thereof, the second actuator being configured to receive and engage a second elongate element manipulable to remotely detach the delivery tube from the valve prosthesis, and being reciprocally actuatable with respect to the body for manipulating the second elongate element by causing the second elongate element to translate with respect to the delivery tube along the longitudinal axis. - View Dependent Claims (24, 25)
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Specification