METHODS AND DEVICES FOR RENAL NERVE BLOCKING
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Accused Products
Abstract
A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.
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Citations
139 Claims
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1-23. -23. (canceled)
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24. An implantable system for treating a patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, renal disease, or chronic renal failure, the system comprising:
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a drug delivery device having a proximal section and a distal section, wherein the distal section is configured to be at least partially implanted within a periarterial space of the patient; an implantable drug pump operatively connected to the proximal section of the drug delivery device, wherein the implantable drug pump further includes a drug reservoir; and a controller configured to operate instructions that cause the implantable drug pump to deliver via the drug delivery device a neuromodulatory agent to a nerve that innervates a kidney of the patient in an amount and for a duration sufficient to modulate at least one of urine production, blood pressure, fluid retention, renin secretion, renal blood flow, waste excretion, and sodium retention in the patient. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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66. An apparatus for treating a patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, renal disease, or chronic renal failure, the apparatus comprising:
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an implantable catheter having a proximal section and a distal section, wherein the distal section is configured to be at least partially positioned within a periarterial space of the patient; and a subcutaneous injection port operatively connected to the proximal section of the implantable catheter, wherein the subcutaneous injection port is configured to receive an injection of a neuromodulatory agent and supply the neuromodulatory agent via the implantable catheter to a nerve that innervates a kidney of the patient in an amount and for a duration sufficient to modulate at least one of urine production, blood pressure, fluid retention, renin secretion, renal blood flow, waste excretion, and sodium retention in the patient. - View Dependent Claims (67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93)
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94. An apparatus for treating a patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, renal disease, or chronic renal failure, the apparatus comprising:
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a drug delivery device configured to be at least partially positioned in a periarterial space of the patient; an electrode configured to be positioned proximate to a nerve that innervates a kidney of the patient; and an energy generator operatively coupled to at least one of the drug delivery device and the electrode. - View Dependent Claims (95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119)
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120. An apparatus for at least partially blocking a renal nerve of a kidney of a human patient, the apparatus comprising:
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a drug eluting device configured for placement in a periarterial space of the patient, wherein the drug eluting device is loaded with a diffusible supply of a nerve-blocking drug for delivery to the periarterial space in an amount and for a duration sufficient to modulate at least one of urine production, blood pressure, fluid retention, renin secretion, renal blood flow, waste excretion, and sodium retention in the patient. - View Dependent Claims (121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131)
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132. An apparatus for treating a patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, renal disease, or chronic renal failure, the apparatus comprising:
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a first drug delivery device configured to be positioned proximate to a first nerve that innervates a first kidney of the patient; and a second drug delivery device configured to be positioned proximate to a second nerve that innervates a second kidney of the patient, wherein the first drug delivery device is configured to deliver a nerve-blocking agent to the first nerve that innervates the first kidney and inhibit neural activity along the first nerve, and the second drug delivery device is configured to deliver the nerve-blocking agent to the second nerve that innervates the second kidney and inhibit neural activity along the second nerve, and wherein the nerve-blocking agent is delivered by the first and second drug delivery devices in an amount and for a period of time sufficient to modulate at least one urine production, blood pressure, fluid retention, renin secretion, renal blood flow, waste excretion, and sodium retention in the patient. - View Dependent Claims (133, 134, 135, 136, 137, 138, 139)
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Specification