SYNTHETIC PLATELETS
First Claim
1. A method for preparing a synthetic platelet substitute comprising a receptor molecule and a carrier molecule, said method comprising:
- a. preparing a carrier molecule comprising lipidic particles with a cross-linked surface mesh byi. preparing lipidic particles comprising pharmaceutically acceptable lipids,ii. binding hydrophilic polymer chains to the surface of the lipidic particles, andiii. cross-linking the hydrophilic polymer chains to form the cross-linked surface mesh; and
b. attaching at least one receptor molecule to the surface of the carrier molecule, wherein the receptor molecule is a peptide selected from the group consisting of SEQ ID NO;
1, SEQ ID NO;
2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
7, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, analogs thereof having 90% sequence identity, and modified peptides thereof having an insertion of a Cys residue and/or a spectrophotometrically traceable amino acid and/or a poly-Gly tag consisting of 1 to 5 Gly residues.
5 Assignments
0 Petitions
Accused Products
Abstract
A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids; hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.
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Citations
21 Claims
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1. A method for preparing a synthetic platelet substitute comprising a receptor molecule and a carrier molecule, said method comprising:
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a. preparing a carrier molecule comprising lipidic particles with a cross-linked surface mesh by i. preparing lipidic particles comprising pharmaceutically acceptable lipids, ii. binding hydrophilic polymer chains to the surface of the lipidic particles, and iii. cross-linking the hydrophilic polymer chains to form the cross-linked surface mesh; and b. attaching at least one receptor molecule to the surface of the carrier molecule, wherein the receptor molecule is a peptide selected from the group consisting of SEQ ID NO;
1, SEQ ID NO;
2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
7, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, analogs thereof having 90% sequence identity, and modified peptides thereof having an insertion of a Cys residue and/or a spectrophotometrically traceable amino acid and/or a poly-Gly tag consisting of 1 to 5 Gly residues. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising:
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a. a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising;
an inner lipidic particle of pharmaceutically acceptable particle-forming lipids;
hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and
cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; andb. at least one receptor molecule attached to the surface of the carrier molecule, wherein the receptor molecule is a peptide selected from the group consisting of SEQ ID NO;
1, SEQ ID NO;
2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
7, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, analogs thereof having 90% sequence identity, and modified peptides thereof having an insertion of a Cys residue and/or a spectrophotometrically traceable amino acid and/or a poly-Gly tag consisting of 1 to 5 Gly residues.
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21. An antithrombotic composition that interacts with platelets and the (sub)endothelium, comprising:
- a peptide selected from the group consisting of SEQ ID NO;
1, SEQ ID NO;
2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
7, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, analogs thereof having 90% sequence identity, modified peptides thereof having an insertion of a Cys residue and/or a spectrophotometrically traceable amino acid and/or a poly-Gly tag consisting of 1 to 5 Gly residues, and combinations thereof
- a peptide selected from the group consisting of SEQ ID NO;
Specification