Delivery of Nanoparticles and/or Agents to Cells
First Claim
Patent Images
1. A conjugate comprising:
- a nanoparticle;
at least one modulating entity; and
at least one agent to be delivered.
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Abstract
The present invention provides systems, methods, and compositions for targeted delivery of nanoparticles and/or agents to tissues, cells, and/or subcellular locales. In general, compositions comprise a nanoparticle (e.g. quantum dot, polymeric particle, etc.), at least one modulating entity (such as a targeting moiety, transfection reagent, protective entity, etc.), and at least one agent to be delivered (e.g. therapeutic, prophylactic, and/or diagnostic agent). The present invention provides methods of making and using nanoparticle entities in accordance with the present invention.
275 Citations
88 Claims
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1. A conjugate comprising:
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a nanoparticle; at least one modulating entity; and at least one agent to be delivered. - View Dependent Claims (2, 6, 10, 11, 21, 23, 28, 31, 36, 47, 49, 51, 52, 73, 74, 75)
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3-5. -5. (canceled)
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7-9. -9. (canceled)
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12-20. -20. (canceled)
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22. (canceled)
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24-27. -27. (canceled)
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29-30. -30. (canceled)
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32-35. -35. (canceled)
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37-46. -46. (canceled)
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48. (canceled)
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50. (canceled)
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53-66. -66. (canceled)
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67. A conjugate comprising:
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a nanoparticle; a modulating entity; polyethylene glycol (PEG); and an agent to be delivered.
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68-72. -72. (canceled)
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76-86. -86. (canceled)
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87. A method comprising steps of:
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providing; a nanoparticle; at least one modulating entity; and at least one agent to be delivered; and contacting the nanoparticle, at least one modulating entity, and at least one agent to be delivered such that the nanoparticle, at least one modulating entity, and at least one agent become physically associated with one another.
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88. A method comprising steps of:
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providing; a nanoparticle; at least one modulating entity; and at least one agent to be delivered; and contacting the nanoparticle and the at least one modulating entity to allow formation of a complex comprising the nanoparticle and the modulating entity; and contacting the complex with the agent to be delivered.
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Specification