ANTI-HUMAN PAPILLOMAS VIRUS TOPICAL COMPOSITION

• US 20080213410A1
• Filed: 02/07/2008
• Published: 09/04/2008
• Est. Priority Date: 02/08/2007
• Status: Abandoned Application

• Current Assignee: Michel Serrano
• Original Assignee: Michel Serrano
• Inventors: Serrano, Michel
• Application Number:
  US12/027,558
• Publication Number:
  US 20080213410A1
• Time in Patent Office: Days
• US Class Current: 424/754
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/81 Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
• CPC Class Codes: A61K 36/8962 Allium, e.g. garden onion, leek, garlic or chives
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61P 17/12 Keratolytics, e.g. wart or anti-corn preparations
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/20 for DNA viruses

Abstract

The present invention relates to a topical composition for reducing lesion and inflammation of human papillomavirus (HPV) on the skin and mucous membranes comprising an effective amount of at least one component from one of ground garlic, garlic powder, garlic oil, minced garlic, and greater celandine, a terpene-, phenol- or polyphenol-containing agent, and a sulfurated compound in association with a pharmaceutically acceptable carrier to form a homogenous topical composition, and method of treatment thereof.

Claims

1. A topical composition for reducing lesion and inflammation of human papillomavirus (HPV) on the skin and mucous membranes comprising an effective amount of at least one component from a) to c):

a) one of ground garlic, garlic powder, garlic oil, minced garlic and greater celandine;

b) a terpene-, phenol- or polyphenol-containing agent; and

c) a sulfurated compound

in association with a pharmaceutically acceptable carrier to form a homogenous topical composition.

2. The topical composition according to claim 1, wherein said garlic powder is present in the composition in a dose consisting of 36 mg per 1 g of a pharmaceutically acceptable carrier.

3. The topical composition according to claim 1, wherein said greater celandine is present in the composition in a dose consisting of 6 drops per 15 g of a pharmaceutically acceptable carrier.

4. The topical composition according to claim 1, wherein said terpene-, phenol- or polyphenol-containing agent is an essential oil selected from the group consisting of thuja oil, eucalyptus oil, birch oil, Atlantic cedar oil, red thyme oil, oregano oil, tarragon oil, red cedar wood oil, basil oil, and combination thereof.

6. The topical composition according to claim 1, said terpene-, phenol- or polyphenol-containing agent is capsaicin or cayenne pepper.

7. The topical composition according to claim 1, wherein said sulfurated compound is methyl-sulphone-methane or methylsulfonylfluoride.

8. The topical composition according to claim 7, wherein said methyl-sulphone-methane is present in the composition in a dose consisting of 1000 mg per 15 g of a pharmaceutically acceptable carrier and methylsulfonylfluoride is present in the composition in a dose consisting of 12 mg per 15 g of a pharmaceutically acceptable carrier.

9. The topical composition according to claim 1, wherein said pharmaceutically acceptable carrier consists of a lotion or an ointment.

10. A method for reducing lesion and inflammation caused by HPV related infections on skin and mucous membranes of a patient, comprising administering topically a sufficient amount of the topical composition of claim 1 to the skin or mucous membrane of a patient.

11. The method for the treatment according to claim 10, wherein said lesion is a wart.

12. The method for the treatment according to claim 11 wherein said wart an acute or chronic wart.

13. The method for the treatment according to claim 12, wherein said wart is a genital wart.

14. The method for the treatment according to claim 13, wherein said skin and mucous membranes consist of the skin of the penis, vulva (area outside the vagina), anus, scrotum, groin, or thigh and in the linings of the vagina, cervix, or rectum.

15. The method for the treatment according to claim 14, wherein administering topically is effected by swiping the surface of the skin or mucous membrane to be treated with a swab containing the composition in the case of an acute wart.

16. The method for the treatment according to claim 12, wherein administering topically is subcutaneous or transdermal in situ in the case of a chronic wart.

17. The method for the treatment according to claim 16, wherein said transdermal topical administration consists of inserting subcutaneously in situ the composition under the skin or mucous membrane of the subject with a microlet or applying in situ to the skin of the subject a transdermal patch diffusing the composition trough the skin or mucous membrane over an extended period of time.

5. The topical composition according to claim 5, wherein said essential oil is present in the composition in a dose consisting of 12 drops per 15 g of a pharmaceutically acceptable carrier.