Coated Microstructures and Methods of Manufacture Thereof
First Claim
Patent Images
1. A microneedle device for insertion of a drug into a biological tissue comprising:
- at least one microneedle having a base, a tip end, and a shaft portion therebetween; and
a coating on at least a portion of the surface of the at least one microneedle, the coating comprising at least one drug and a viscosity enhancer.
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Accused Products
Abstract
Coated microneedle devices and methods of making such devices are provided. In one aspect, a method for coating includes providing a microstructure having at least one surface in need of coating; and applying a coating liquid, which comprises at least one drug, to the at least one surface of the microstructure, wherein the surface energy of the coating liquid is less than the surface energy of the surface of the microstructure. The coating liquid may include a viscosity enhancer and surfactant. Microneedles having heterogeneous coatings, pockets, or both are also provided.
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Citations
66 Claims
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1. A microneedle device for insertion of a drug into a biological tissue comprising:
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at least one microneedle having a base, a tip end, and a shaft portion therebetween; and a coating on at least a portion of the surface of the at least one microneedle, the coating comprising at least one drug and a viscosity enhancer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 27, 28, 29)
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21. A microneedle device for insertion of a drug into a biological tissue comprising:
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at least one microneedle having a base, a tip end, and a shaft portion therebetween; and a coating on at least a portion of the surface of the at least one microneedle, the coating comprising at least one drug, wherein the coating has a heterogeneous composition. - View Dependent Claims (22, 23)
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24. A microneedle device for insertion of a drug into a biological tissue comprising:
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at least one microneedle having a base, a tip end, and a shaft portion therebetween; and a coating on at least a portion of the surface of the at least one microneedle, the coating comprising at least one drug, wherein the shaft portion of the at least one microneedle comprises one or more pockets therein. - View Dependent Claims (25, 26)
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30. (canceled)
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31. A method for coating a microstructure comprising:
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providing a microstructure having at least one surface in need of coating; and applying a coating liquid, which comprises at least one drug, to the at least one surface of the microstructure, wherein the surface energy of the coating liquid is less than the surface energy of the surface of the microstructure.
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32-46. -46. (canceled)
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47. A method for coating at least one microneedle comprising:
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providing a coating liquid disposed in one or more reservoirs, the coating liquid comprising at least one drug; providing a physical mask having one or more apertures, each aperture having cross-sectional dimensions larger than the at least one microneedle to be coated; aligning the at least one microneedle with at least one of the one or more apertures; inserting the at least one microneedle through the aligned aperture and into the coating liquid, thereby coating at least a portion of the microneedle; and removing the coated microneedle from the coating liquid and from the aperture. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54)
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55-62. -62. (canceled)
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63. A method of making a microneedle device comprising:
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forming one or more microneedles from a metal; and electropolishing the one or more microneedles to smooth the surfaces of the microneedles.
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64. (canceled)
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65. A microneedle patch comprising:
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an array two or more microneedles extending out of plane from a substrate; and an adhesive material disposed between the two or more microneedles, the adhesive material comprising an adhesive suitable for removably securing the microneedle patch to a patient'"'"'s skin.
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66-67. -67. (canceled)
Specification